Muro Antonio, Pérez-Arellano José-Luís
Laboratorio de Inmunología Parasitaria y Molecular, Centro de Investigación de Enfermedades Tropicales de la Universidad de Salamanca, Campus Miguel de Unamuno s/n, 37007 Salamanca, Spain.
J Biomed Biotechnol. 2010;2010:958108. doi: 10.1155/2010/958108. Epub 2010 Feb 3.
Nitric oxide (NO) is a very simple molecule that displays very important functions both in helminths (mainly those involved in respiratory pathology) and in mammalian hosts. In this paper we review four issues related to interaction of NO and lung helminthic diseases. Firstly, we evaluated data available on the NO synthesis and release by helminths and their biological role. Next, we summarized the effect of antigens obtained from different phases of the biological cycle on NO production by host mammalian cells (mainly from human sources). Thirdly, we revised the evaluation of NO on the biological activities and/or the viability of respiratory helminths. Lastly, the deleterious consequences of increased production of NO during helminthic human infection are detailed.
一氧化氮（NO）是一种非常简单的分子，它在蠕虫（主要是那些与呼吸道病理学有关的蠕虫）和哺乳动物宿主中都发挥着非常重要的功能。在本文中，我们综述了与NO和肺部蠕虫病相互作用相关的四个问题。首先，我们评估了关于蠕虫产生和释放NO的数据及其生物学作用。其次，我们总结了从生物周期不同阶段获得的抗原对宿主哺乳动物细胞（主要来自人类）产生NO的影响。第三，我们修订了对NO对呼吸道蠕虫的生物学活性和/或生存能力的评估。最后，详细阐述了人类蠕虫感染期间NO产生增加的有害后果。
