Bozkaya Hakan, Yurdaydin Cihan, Törüner Murat, Arat Mutlu, Bozdayi A Mithat, Erekul Selim, Cinar Kubilay, Koç Haluk, Uzunalimoğlu Ozden
Department of Gastroenterology, University of Ankara Medical School, Turkey.
Dig Dis Sci. 2002 Aug;47(8):1782-5. doi: 10.1023/a:1016444611997.
Although viral hepatitis infection is known to be associated with aplastic anemia, a causal link between viral hepatitis and aplastic anemia has not been convincingly demonstrated. A case of hepatitis B-associated severe aplastic anemia is described which only partially responded to conventional immunosuppressive treatment but went into complete clinical remission after clearance of the hepatitis B virus. Disappearance of the hepatitis B virus occurred during lamivudine treatment and coincided with immune activation secondary to discontinuation of immunosuppressive therapy. This case was somewhat atypical in that a history of acute hepatitis preceding the aplastic anemia was absent. The observation made in this case report supports a cause-effect relationship between hepatitis B virus infection and aplastic anemia.
虽然已知病毒性肝炎感染与再生障碍性贫血有关，但病毒性肝炎与再生障碍性贫血之间的因果关系尚未得到令人信服的证实。本文描述了一例乙型肝炎相关的严重再生障碍性贫血病例，该病例对传统免疫抑制治疗仅部分有效，但在乙型肝炎病毒清除后实现了完全临床缓解。乙型肝炎病毒的清除发生在拉米夫定治疗期间，且与免疫抑制治疗中断继发的免疫激活同时出现。该病例有些不典型，因为在再生障碍性贫血之前没有急性肝炎病史。本病例报告中的观察结果支持乙型肝炎病毒感染与再生障碍性贫血之间的因果关系。
