Meurs Kathryn M, Spier Alan W, Wright Nicola A, Atkins Clarke E, DeFrancesco Teresa C, Gordon Sonya G, Hamlin Robert L, Keene Bruce W, Miller Matthew W, Moise N Sydney
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus 43210, USA.
J Am Vet Med Assoc. 2002 Aug 15;221(4):522-7. doi: 10.2460/javma.2002.221.522.
To evaluate the effect of 4 antiarrhythmic treatment protocols on number of ventricular premature complexes (VPC), severity of arrhythmia, heart rate (HR), and number of syncopal episodes in Boxers with ventricular tachyarrhythmias.
Randomized controlled clinical trial.
49 Boxers.
Dogs with > 500 VPC/24 h via 24-hour ambulatory ECG (AECG) were treated with atenolol (n = 11), procainamide (11), sotalol (16), or mexiletine and atenolol (11) for 21 to 28 days. Results of pre- and posttreatment AECG were compared with regard to number of VPC/24 h; maximum, mean, and minimum HR; severity of arrhythmia; and occurrence of syncope.
Significant differences between pre- and posttreatment number of VPC, severity of arrhythmia, HR variables, or occurrence of syncope were not observed in dogs treated with atenolol or procainamide. Significant reductions in number of VPC, severity of arrythmia, and maximum and mean HR were observed in dogs treated with mexiletine-atenolol or sotalol; occurrence of syncope was not significantly different between these 2 treatment groups.
Treatment with sotalol or mexiletine-atenolol was well tolerated and efficacious. Treatment with procainamide or atenolol was not effective.
评估4种抗心律失常治疗方案对患有室性心律失常的拳师犬室性早搏复合体（VPC）数量、心律失常严重程度、心率（HR）和晕厥发作次数的影响。
随机对照临床试验。
49只拳师犬。
通过24小时动态心电图（AECG）检测，VPC/24小时>500次的犬只分别接受阿替洛尔（n = 11）、普鲁卡因胺（11）、索他洛尔（16）或美西律与阿替洛尔联合治疗（11），持续21至28天。比较治疗前后AECG结果的VPC/24小时数量、最大、平均和最小心率、心律失常严重程度以及晕厥发生情况。
接受阿替洛尔或普鲁卡因胺治疗的犬只，治疗前后VPC数量、心律失常严重程度、心率变量或晕厥发生情况均未观察到显著差异。接受美西律 - 阿替洛尔或索他洛尔治疗的犬只，VPC数量、心律失常严重程度以及最大和平均心率均显著降低；这两个治疗组之间晕厥发生率无显著差异。
索他洛尔或美西律 - 阿替洛尔治疗耐受性良好且有效。普鲁卡因胺或阿替洛尔治疗无效。
