急性服用西酞普兰会使血浆和唾液中的皮质醇水平相应升高。
Acute citalopram administration produces correlated increases in plasma and salivary cortisol.
作者信息
Bhagwagar Z, Hafizi S, Cowen P J
机构信息
University Department of Psychiatry, Warneford Hospital, Oxford OX3 7JX, UK.
出版信息
Psychopharmacology (Berl). 2002 Aug;163(1):118-20. doi: 10.1007/s00213-002-1149-4. Epub 2002 Jun 27.
RATIONALE
Intravenous administration of the selective serotonin (5-HT) re-uptake inhibitor, citalopram, increases plasma cortisol. This would be expected to produce a parallel increase in salivary cortisol concentration.
OBJECTIVE
To find out whether IV citalopram produces correlated increases in plasma and salivary cortisol levels.
METHODS
Twelve healthy volunteers were tested on two occasions receiving either citalopram (10 mg IV) or saline in a double-blind, randomised, cross-over design. Plasma and salivary cortisol levels were measured before and for 150 min after each infusion.
RESULTS
Relative to placebo, citalopram significantly increased cortisol levels in both plasma and saliva. The size of the increases in plasma and saliva cortisol correlated significantly with each other.
CONCLUSIONS
Monitoring changes in salivary cortisol might be a valid and acceptable means of measuring 5-HT-mediated cortisol release.
理论依据
静脉注射选择性5-羟色胺（5-HT）再摄取抑制剂西酞普兰可提高血浆皮质醇水平。由此预计唾液皮质醇浓度会相应升高。
目的
探究静脉注射西酞普兰是否会使血浆和唾液皮质醇水平同步升高。
方法
采用双盲、随机、交叉设计，12名健康志愿者分两次接受测试，分别注射西酞普兰（静脉注射10毫克）或生理盐水。每次注射前及注射后150分钟测量血浆和唾液皮质醇水平。
结果
与安慰剂相比，西酞普兰显著提高了血浆和唾液中的皮质醇水平。血浆和唾液中皮质醇升高的幅度显著相关。
结论
监测唾液皮质醇的变化可能是测量5-HT介导的皮质醇释放的一种有效且可接受的方法。
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