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人体三叉气道模型中微颗粒沉积的计算分析

Computational analysis of micron-particle deposition in a human triple bifurcation airway model.

作者信息

Zhang Z, Kleinstreuer C, Kim C S

机构信息

Center for Environmental Medicine and Lung Biology, The University of North Carolina, Chapel Hill, NC 27599, USA.

出版信息

Comput Methods Biomech Biomed Engin. 2002 Apr;5(2):135-47. doi: 10.1080/10255840290032153.


DOI:10.1080/10255840290032153
PMID:12186723
Abstract

Steady laminar axisymmetric inhalation flow and wall deposition of micron-size particles in representative triple bifurcation airways have been simulated using a commercial finite-volume code with user-enhanced programs. Assuming spherical non-interacting particles (3 microm</=d(p)</=7 microm), various inlet Reynolds numbers (Re=500-2000) and Stokes numbers (St=0.02-0.23) were considered. The resulting particle deposition patterns were analyzed and then summarized in terms of deposition efficiencies, i.e. DE=DE(Re,St) Surprisingly high DE-values occur at relatively low Reynolds numbers (e.g., Re=500) in the third bifurcation. The quantitative results are of interest to researchers either conducting health risk assessment studies for inhaled particulate pollutants or analyzing drug aerosol inhalation and deposition at desired lung target sites.

摘要

利用带有用户增强程序的商业有限体积代码,模拟了代表性三级分支气道中稳定的层流轴对称吸入流以及微米级颗粒的壁面沉积情况。假设颗粒为球形且互不作用(3微米≤d(p)≤7微米),考虑了各种入口雷诺数(Re = 500 - 2000)和斯托克斯数(St = 0.02 - 0.23)。对所得的颗粒沉积模式进行了分析,然后根据沉积效率进行了总结,即DE = DE(Re, St)。在相对较低的雷诺数(例如,Re = 500)下,三级分支处出现了出奇高的DE值。这些定量结果对于从事吸入颗粒污染物健康风险评估研究或分析药物气雾剂在期望肺靶位的吸入和沉积的研究人员来说很有意义。

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