Farkas Arpád, Balásházy Imre
Hungarian Academy of Sciences KFKI Atomic Energy Research Institute, P.O. Box 49, 1525 Budapest, Hungary.
Comput Biol Med. 2008 Apr;38(4):508-18. doi: 10.1016/j.compbiomed.2008.01.014. Epub 2008 Mar 11.
The primary objective of this study was to quantify the local inspiratory and expiratory aerosol deposition in a highly asymmetric five-generation tracheobronchial tree. User-enhanced commercial codes and self-developed software was used to compute the air velocity field as well as particle deposition distributions for a large size range of inhalable particles. The numerical model was validated by comparison of our results with experimental flow measurements and particle deposition data available in the open literature. Our simulations show highly localised deposition patterns for all particle sizes, but mainly for the larger particles. As expected, deposition efficiencies and deposition fractions proved to be very sensitive to the particle size. The deposition density in the hot spots can be hundreds and even thousand times higher than the mean deposition density. Present results can be of interest to researchers involved in the assessment of adverse health effects of inhaled aerosols or optimising the drug aerosol delivery into the lung.
本研究的主要目的是量化高度不对称的五代气管支气管树中的局部吸气和呼气气溶胶沉积。使用用户增强的商业代码和自行开发的软件来计算大尺寸范围内可吸入颗粒的空气速度场以及颗粒沉积分布。通过将我们的结果与公开文献中可用的实验流动测量和颗粒沉积数据进行比较，对数值模型进行了验证。我们的模拟显示，所有粒径的颗粒都有高度局部化的沉积模式，但主要是较大颗粒。正如预期的那样，沉积效率和沉积分数对粒径非常敏感。热点处的沉积密度可能比平均沉积密度高数百倍甚至数千倍。目前的结果可能会引起参与评估吸入气溶胶对健康的不利影响或优化药物气溶胶肺部递送的研究人员的兴趣。
