Takeda Takashi, Minekawa Ryoko, Makino Mayuko, Sugiyama Takashi, Murata Yuji, Suehara Noriyuki
Department of Obstetrics and Gynecology, Osaka Medical Center Maternal and Child Health, Osaka, Japan.
Gynecol Obstet Invest. 2002;53(4):243-6. doi: 10.1159/000064566.
Twin-to-twin transfusion syndrome (TTTS) is a severe complication of monochorionic twin pregnancies, with high perinatal loss and significant morbidity. The etiology of this syndrome remains unclear. Hyperreactio luteinalis is a rare benign condition characterized by maternal ovarian enlargement due to theca lutein cysts. We present 4 cases of hyperreactio luteinalis associated with severe TTTS. We detected maternal ovarian enlargement by prenatal ultrasonography in 2 cases, at the cesarean section in 1 case, and postpartum in 1 case. Three cases showed hydrops fetalis and all cases showed congestive cardiac failure. Serial amnioreduction was performed in all cases, and regression of hydrops fetalis and maternal ovarian enlargement occurred in 1 case. These cases suggest that the pathophysiology of TTTS is closely related to the etiology of hyperreactio luteinalis.
双胎输血综合征（TTTS）是单绒毛膜双胎妊娠的一种严重并发症，围产期死亡率高且发病率显著。该综合征的病因尚不清楚。卵巢过度刺激综合征是一种罕见的良性疾病，其特征是由于黄素囊肿导致母体卵巢增大。我们报告4例与严重TTTS相关的卵巢过度刺激综合征。2例通过产前超声检测到母体卵巢增大，1例在剖宫产时发现，1例在产后发现。3例出现胎儿水肿，所有病例均出现充血性心力衰竭。所有病例均进行了系列羊水减量术，1例胎儿水肿和母体卵巢增大消退。这些病例表明，TTTS的病理生理学与卵巢过度刺激综合征的病因密切相关。
