Wiwanitkit Viroj, Preechakas Paungpayom, Bhokaisawan Narudee, Boonchalermvichian Chaiyaporn
Department of Laboratory Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
J Med Assoc Thai. 2002 Jun;85 Suppl 1:S241-5.
Transferrin receptor (TfR) is a glycoprotein which mediates the entry of ferric transferrin from the extracellular compartment into the cells. The measurement of sTfR has become a widely used tool in assessing erythropoiesis but its use has mainly been restricted to research laboratory settings. In Thailand, there are only a few reports concerning the sTfR. The authors studied the expected value of sTFR as well as other basic parameters for monitoring of erythropoiesis as erythropoietin (EPO) and ferritin among a sample of non-anemic healthy Thai children. In addition, correlation was done between each pair of studied parameters. Expected range for sTfR level for the healthy controls in this study was 1.761 to 2.034 mg/L. Expected range for serum EPO level for the healthy controls in this study was 19.445 to 34.176 mU/ml. Expected range for serum ferritin level for the healthy control from this study was 67.895 to 96.692 ng/ml. Of interest, poor correlation among the three studied parameters, sTfR, serum EPO and serum ferritin was observed in this study.
转铁蛋白受体(TfR)是一种糖蛋白,它介导三价铁转铁蛋白从细胞外间隙进入细胞。可溶性转铁蛋白受体(sTfR)的检测已成为评估红细胞生成的一种广泛应用的工具,但其应用主要局限于研究实验室环境。在泰国,关于sTfR的报道较少。作者研究了非贫血健康泰国儿童样本中sTFR以及用于监测红细胞生成的其他基本参数,如促红细胞生成素(EPO)和铁蛋白的预期值。此外,还对每对研究参数进行了相关性分析。本研究中健康对照组的sTfR水平预期范围为1.761至2.034mg/L。本研究中健康对照组的血清EPO水平预期范围为19.445至34.176mU/ml。本研究中健康对照组的血清铁蛋白水平预期范围为67.895至96.692ng/ml。有趣的是,本研究观察到sTfR、血清EPO和血清铁蛋白这三个研究参数之间的相关性较差。