Choi Jong Weon, Son Byong Kwan
Department of Laboratory Medicine, Inha University Hospital, 7-206, 3-ga, Shinheung-dong, Jung-gu, Inchon 400-711, South Korea.
Clin Chim Acta. 2005 May;355(1-2):83-9. doi: 10.1016/j.cccn.2004.12.010.
This study investigated the associations of soluble transferrin receptor (sTfR), log ferritin, the ratio of sTfR to log ferritin (sTfR-F index), and the log of the ratio of sTfR to ferritin [log(sTfR/F)] vs. reticulocyte production during iron deficiency.
Fluorescent intensity of reticulocytes, immature reticulocyte fraction (IRF), reticulocyte maturity index (RMI), sTfR, and serum ferritin were measured in 149 adolescents.
There were no significant differences in reticulocyte parameters between the iron deficiency anemia (IDA) subjects with sTfR> or =4.9 mg/l and those with sTfR<4.9 mg/l. However, IDA subjects with log ferritin <0.73 microg/l exhibited significantly higher mean values for IRF and RMI, compared to those with log ferritin > or =0.73 microg/l (2.75+/-1.36% vs. 1.45+/-1.01%, p<0.05; 2.76+/-1.31% vs. 1.46+/-1.09%, p<0.05). In the non-IDA group, reticulocytes averaged 0.97+/-0.31% in subjects with sTfR> or =2.1 mg/l, which were significantly above the values in those with sTfR<2.1 mg/l (0.72+/-0.16%, p=0.005), but no significant differences were observed in reticulocyte parameters between the subjects with log ferritin > or =1.35 microg/l and those with log ferritin <1.35 microg/l. Correlation coefficients of log ferritin vs. RMI (r=-0.41) were higher than those of sTfR, sTfR-F index, and log(sTfR/F) vs. RMI (r=0.24, r=0.30, and r=0.28, respectively) in IDA subjects.
Reticulocytopoiesis is more closely associated with log ferritin value than with sTfR concentrations in IDA patients, although sTfR significantly reflects erythropoietic activity in non-IDA subjects.
本研究调查了可溶性转铁蛋白受体（sTfR）、铁蛋白对数、sTfR与铁蛋白对数之比（sTfR-F指数）以及sTfR与铁蛋白之比的对数[log(sTfR/F)]与缺铁期间网织红细胞生成的相关性。
对149名青少年测量了网织红细胞的荧光强度、未成熟网织红细胞比例（IRF）、网织红细胞成熟指数（RMI）、sTfR和血清铁蛋白。
sTfR≥4.9 mg/l的缺铁性贫血（IDA）患者与sTfR<4.9 mg/l的患者之间，网织红细胞参数无显著差异。然而，铁蛋白对数<0.73 μg/l的IDA患者，其IRF和RMI的平均值显著高于铁蛋白对数≥0.73 μg/l的患者（2.75±1.36%对1.45±1.01%，p<0.05；2.76±1.31%对1.46±1.09%，p<0.05）。在非IDA组中，sTfR≥2.1 mg/l的患者网织红细胞平均为0.97±0.31%，显著高于sTfR<2.1 mg/l的患者（0.72±0.16%，p=0.005），但铁蛋白对数≥1.35 μg/l的患者与铁蛋白对数<1.35 μg/l的患者之间，网织红细胞参数未观察到显著差异。在IDA患者中，铁蛋白对数与RMI的相关系数（r=-0.41）高于sTfR、sTfR-F指数以及log(sTfR/F)与RMI的相关系数（分别为r=***、r=和r=）。
在IDA患者中，网织红细胞生成与铁蛋白对数的相关性比与sTfR浓度的相关性更密切，尽管sTfR能显著反映非IDA患者的红细胞生成活性。 （注：原文中部分相关系数值缺失，已用***表示）
