Romundstad S, Holmen J, Hallan H, Kvenild K, Krüger O, Midthjell K
HUNT Research Centre, Faculty of Medicine, Norwegian University of Science and Technology (NTNU), Verdal, Norway.
J Intern Med. 2002 Aug;252(2):164-72. doi: 10.1046/j.1365-2796.2002.01025.x.
Microalbuminuria (MA) as an independent marker of cardiovascular morbidity and mortality in nondiabetic/nonhypertensive individuals is under international debate. The aim of this study was to investigate the associations between MA and known cardiovascular risk factors/markers and disease in a randomly selected nondiabetic/nonhypertensive sample.
Cross-sectional study.
Participants in the population-based Nord-Trøndelag Health Study (HUNT), Norway (n = 65 258).
A total of 2113 individuals (> or =20 years), randomly selected without diabetes and treated hypertension, delivered three morning urine samples for MA analysis.
MA expressed as albumin-to-creatinine ratio (ACR), cardiovascular risk factors and disease.
Increasing age, pulse pressure, systolic (SBP) and diastolic blood pressure (DBP) and coronary heart disease (CHD) significantly predicted MA in men and increasing pulse pressure, SBP and DBP were associated with MA in women, adjusted for other cardiovascular risk factors/markers. After excluding individuals with known CHD and untreated hypertension (SBP > or = 140 mmHg, DBP > or = 90 mmHg) and hence a high total risk of cardiovascular disease (CVD), only increasing age was associated with ACR in men and increasing SBP and pulse pressure in women. Smoking, elevated lipid and glucose levels were strongly associated with MA in individuals with a high total risk of CVD than in individuals with a low total risk.
MA was associated with increasing blood pressure in both genders, age and CHD in men. Other cardiovascular risk factors/markers might be more influential in predicting ACR variation in nondiabetic/nonhypertensive individuals with a high total risk of CVD than in individuals with a low total risk.
微量白蛋白尿（MA）作为非糖尿病/非高血压个体心血管发病和死亡的独立标志物，目前仍存在国际争议。本研究旨在调查在随机选取的非糖尿病/非高血压样本中，MA与已知心血管危险因素/标志物及疾病之间的关联。
横断面研究。
挪威基于人群的北特伦德拉格健康研究（HUNT）的参与者（n = 65258）。
总共2113名年龄≥20岁的个体，随机选取，无糖尿病且未接受高血压治疗，提供三份晨尿样本用于MA分析。
以白蛋白与肌酐比值（ACR）表示的MA、心血管危险因素及疾病。
在调整其他心血管危险因素/标志物后，年龄增加、脉压、收缩压（SBP）和舒张压（DBP）升高以及冠心病（CHD）在男性中显著预测MA，脉压、SBP和DBP升高在女性中与MA相关。排除已知患有CHD和未治疗高血压（SBP≥140 mmHg，DBP≥90 mmHg）且因此心血管疾病（CVD）总风险较高的个体后，仅年龄增加与男性的ACR相关，SBP和脉压升高与女性的ACR相关。与CVD总风险低的个体相比，吸烟、血脂和血糖水平升高在CVD总风险高的个体中与MA的关联更强。
MA在两性中均与血压升高相关，在男性中与年龄和CHD相关。与CVD总风险低的个体相比，其他心血管危险因素/标志物在预测CVD总风险高的非糖尿病/非高血压个体的ACR变化方面可能更具影响力。
