Stohl William
Division of Rheumatology, University of Southern California, Keck School of Medicine, Los Angeles 90033, USA.
Curr Opin Rheumatol. 2002 Sep;14(5):522-8. doi: 10.1097/00002281-200209000-00007.
B lymphocyte stimulator (BLyS) protein is among the novel tumor necrosis factor (TNF) ligands and receptor superfamily members recently described. BLyS protein can promote B cell survival, expansion, and differentiation both and. Constitutive overexpression of BLyS protein can result in systemic lupus erythematosus (SLE)-like disease in mice, and circulating levels of BLyS protein are elevated in a subset of human SLE patients. Treatment of SLE mice with a BLyS protein antagonist ameliorates disease progression and enhances survival. By inference, BLyS protein may also play an important contributory role in pathogenesis and/or propagation of human SLE and becomes a legitimate candidate target for antagonist biologic agents.
B淋巴细胞刺激因子（BLyS）蛋白是最近描述的新型肿瘤坏死因子（TNF）配体和受体超家族成员之一。BLyS蛋白可促进B细胞存活、增殖和分化。BLyS蛋白的组成性过表达可导致小鼠出现系统性红斑狼疮（SLE）样疾病，并且在一部分人类SLE患者中，BLyS蛋白的循环水平升高。用BLyS蛋白拮抗剂治疗SLE小鼠可改善疾病进展并提高生存率。由此推断，BLyS蛋白可能在人类SLE的发病机制和/或传播中也起重要作用，并成为拮抗剂生物制剂的合理候选靶点。
