转铁蛋白介导的致病性奈瑟菌铁摄取

Transferrin-mediated iron acquisition by pathogenic Neisseria.

作者信息

Evans R W, Oakhill J S

机构信息

Metalloprotein Research Group, The Randall Centre for Molecular Mechanisms of Cell Function, King's College London, 3.6A New Hunt's House, Guy's Campus, London SE1 1UL, UK.

出版信息

Biochem Soc Trans. 2002 Aug;30(4):705-7. doi: 10.1042/bst0300705.

DOI:10.1042/bst0300705

PMID:12196170

Abstract

The pathogenic Neisseria have a siderophore-independent iron-uptake system reliant on a direct interaction between the bacterial cell and transferrin. In the meningococcus this uptake system is dependent on two surface-exposed transferrin-binding proteins. This short account will review our current knowledge of the transferrin-mediated iron-acquisition system of pathogenic Neisseria.

摘要

致病性奈瑟菌具有一种不依赖铁载体的铁摄取系统，该系统依赖于细菌细胞与转铁蛋白之间的直接相互作用。在脑膜炎奈瑟菌中，这种摄取系统依赖于两种表面暴露的转铁蛋白结合蛋白。本简要综述将概述我们目前对致病性奈瑟菌转铁蛋白介导的铁获取系统的了解。