Bhattacharyya-Pakrasi M, Pakrasi H B, Ogawa T, Aurora R
Department of Biology, Washington University, Campus Box 1137, One Brookings Drive, St. Louis, MO 63130-4899, USA.
Biochem Soc Trans. 2002 Aug;30(4):768-70. doi: 10.1042/bst0300768.
Regulation of manganese acquisition by bacteria occurs by both biochemical regulation of the activity of the transporters and transcriptional regulation of gene expression. Structural analysis suggests that calcium ions may regulate the function of an Mn ATP-binding cassette (ABC)-permease in Synechocystis 6803, a cyanobacterium, as well as in a number of other bacteria. The expression of genes encoding the manganese transporter in Synechocystis 6803 is regulated by a two-component signal-transduction mechanism that has not been previously observed for manganese and zinc transport in bacteria.
细菌对锰摄取的调节通过转运蛋白活性的生化调节和基因表达的转录调节来实现。结构分析表明，钙离子可能调节蓝藻集胞藻6803以及许多其他细菌中锰ATP结合盒（ABC）通透酶的功能。集胞藻6803中编码锰转运蛋白的基因表达受一种双组分信号转导机制调节，这种机制在细菌的锰和锌转运中尚未被观察到。
