Ott Brian R, Belazi Dea, Lapane Kate L
Department of Clinical Neurosciences, Brown University, Providence, Rhode Island, USA.
J Gerontol A Biol Sci Med Sci. 2002 Sep;57(9):M594-8. doi: 10.1093/gerona/57.9.m594.
Clinical and epidemiological research has been done regarding the potential therapeutic benefit of estrogen in outpatients with and without dementia; however, the effects of estrogen therapy on cognition in elderly nursing home patients have not been previously examined.
This retrospective cohort study compared 191 women estrogen users with 663 women nonestrogen users, matched according to age, nursing home facility, year of assessment, and baseline level of cognitive function. The outcome was decline in cognition, measured by the Cognitive Performance Scale, over a minimum follow-up period of 6 months.
No significant difference was found in the rate of cognitive decline among estrogen users and nonusers.
Estrogen therapy administered to nursing home residents is not associated with a reduction in cognitive decline. This study lends further support to recent controlled clinical trials that found no benefit for estrogen treatment on cognition in outpatients with dementia.
关于雌激素对患有和未患痴呆症的门诊患者潜在治疗益处的临床和流行病学研究已经开展；然而，雌激素疗法对老年疗养院患者认知功能的影响此前尚未得到研究。
这项回顾性队列研究将191名使用雌激素的女性与663名未使用雌激素的女性进行了比较，这些女性根据年龄、疗养院设施、评估年份和认知功能基线水平进行匹配。研究结果是通过认知表现量表衡量的认知功能下降，随访期至少为6个月。
使用雌激素者和未使用者的认知功能下降率没有显著差异。
对疗养院居民进行雌激素治疗与认知功能下降的减少无关。这项研究进一步支持了最近的对照临床试验，这些试验发现雌激素治疗对患有痴呆症的门诊患者的认知功能没有益处。
