Theodore W H, Hunter K, Chen R, Vega-Bermudez F, Boroojerdi B, Reeves-Tyer P, Werhahn K, Kelley K R, Cohen L
Clinical Epilepsy, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.
Neurology. 2002 Aug 27;59(4):560-2. doi: 10.1212/wnl.59.4.560.
To perform a controlled trial of transcranial magnetic stimulation (TMS).
Twenty-four patients with localization-related epilepsy were randomized to blinded active or placebo stimulation. Weekly seizure frequency was compared for 8 weeks before and after 1 week of 1-Hz TMS for 15 minutes twice daily.
When the 8-week baseline and post-stimulation periods were compared, active patients had a mean seizure frequency reduction of 0.045 +/- 0.13 and sham-stimulated control subjects -0.004 +/- 0.20. Over 2 weeks, actively treated patients had a mean reduction in weekly seizure frequency of 0.16 +/- 0.18 and sham-stimulated control subjects 0.01 +/- 0.24. Neither difference was significant.
The effect of TMS on seizure frequency was mild and short lived.
进行一项经颅磁刺激（TMS）的对照试验。
24例定位相关癫痫患者被随机分为接受盲法主动刺激或安慰剂刺激组。在每天两次15分钟的1赫兹TMS治疗1周前后，比较8周的每周癫痫发作频率。
比较8周的基线期和刺激后期，主动刺激组患者的癫痫发作频率平均降低0.045±0.13，假刺激对照组患者降低0.004±0.20。在2周内，接受积极治疗的患者每周癫痫发作频率平均降低0.16±0.18，假刺激对照组患者降低0.01±0.24。两者差异均无统计学意义。
TMS对癫痫发作频率的影响轻微且短暂。
