Elbl L
Oddĕlení funkcního vysetrování FN Brno.
Vnitr Lek. 2002 Jul;48(7):619-25.
The author presents a review of cardiovascular complications of anti-tumourous treatment. Cardiovascular toxicity is an interdisciplinary problem which can lead to serious complications of oncological treatment and considerably reduce its benefit for the patient. Cytostatics can produce a number of undesirable side-effects such as arrhythmias, angina pectoris, acute myocardial infarction, sudden death, cardiac failure. The most serious cardiotoxicity is probably chronic cardiac failure after anthracycline treatment. Interest in the diagnosis, monitoring and treatment of cardiotoxicity was aroused by new findings of cardiac complications after some cytostatics, high dosage chemotherapy and transplantation of haematopoietic cells.
作者对抗肿瘤治疗的心血管并发症进行了综述。心血管毒性是一个跨学科问题,可导致肿瘤治疗的严重并发症,并大大降低其对患者的益处。细胞抑制剂可产生多种不良副作用,如心律失常、心绞痛、急性心肌梗死、猝死、心力衰竭。最严重的心脏毒性可能是蒽环类药物治疗后的慢性心力衰竭。某些细胞抑制剂、高剂量化疗和造血细胞移植后心脏并发症的新发现引发了人们对心脏毒性诊断、监测和治疗的关注。