相似文献
1
Suppression of the STK15 oncogenic activity requires a transactivation-independent p53 function.抑制STK15致癌活性需要一种不依赖于反式激活的p53功能。
EMBO J. 2002 Sep 2;21(17):4491-9. doi: 10.1093/emboj/cdf409.
2
The centrosomal kinase Aurora-A/STK15 interacts with a putative tumor suppressor NM23-H1.中心体激酶Aurora-A/STK15与一种假定的肿瘤抑制因子NM23-H1相互作用。
Nucleic Acids Res. 2002 Dec 15;30(24):5465-75. doi: 10.1093/nar/gkf678.
3
Frequent overexpression of STK15/Aurora-A/BTAK and chromosomal instability in tumorigenic cell cultures derived from human ovarian cancer.在源自人类卵巢癌的致瘤性细胞培养物中，STK15/Aurora - A/BTAK频繁过表达且存在染色体不稳定现象。
Oncol Res. 2005;15(1):49-57. doi: 10.3727/096504005775082101.
4
Phosphorylation by aurora kinase A induces Mdm2-mediated destabilization and inhibition of p53.极光激酶A介导的磷酸化作用可诱导Mdm2介导的p53蛋白不稳定及抑制作用。
Nat Genet. 2004 Jan;36(1):55-62. doi: 10.1038/ng1279. Epub 2003 Dec 14.
5
Aurora-A abrogation of p53 DNA binding and transactivation activity by phosphorylation of serine 215.极光激酶A通过丝氨酸215磷酸化消除p53的DNA结合和反式激活活性。
J Biol Chem. 2004 Dec 10;279(50):52175-82. doi: 10.1074/jbc.M406802200. Epub 2004 Oct 6.
6
Novel human p53 mutations that are toxic to yeast can enhance transactivation of specific promoters and reactivate tumor p53 mutants.对酵母有毒性的新型人类p53突变可增强特定启动子的反式激活作用并重新激活肿瘤p53突变体。
Oncogene. 2001 Jun 7;20(26):3409-19. doi: 10.1038/sj.onc.1204457.
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Dynamic association of a tumor amplified kinase, Aurora-A, with the centrosome and mitotic spindle.一种肿瘤扩增激酶Aurora-A与中心体和有丝分裂纺锤体的动态关联。
Cell Motil Cytoskeleton. 2003 Jun;55(2):134-46. doi: 10.1002/cm.10120.
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Direct evidence for the role of centrosomally localized p53 in the regulation of centrosome duplication.中心体定位的p53在中心体复制调控中作用的直接证据。
Oncogene. 2007 May 3;26(20):2939-44. doi: 10.1038/sj.onc.1210085. Epub 2006 Oct 30.
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Aurora-A overexpression reveals tetraploidization as a major route to centrosome amplification in p53-/- cells.极光激酶A的过表达揭示了四倍体化是p53基因敲除细胞中中心体扩增的主要途径。
EMBO J. 2002 Feb 15;21(4):483-92. doi: 10.1093/emboj/21.4.483.
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Serine15 phosphorylation stimulates p53 transactivation but does not directly influence interaction with HDM2.丝氨酸15磷酸化刺激p53反式激活，但不直接影响其与HDM2的相互作用。
EMBO J. 1999 Dec 15;18(24):7002-10. doi: 10.1093/emboj/18.24.7002.
引用本文的文献
1
TF-DUBTACs Stabilize Tumor Suppressor Transcription Factors.TF-DUBTACs 稳定肿瘤抑制转录因子。
J Am Chem Soc. 2022 Jul 20;144(28):12934-12941. doi: 10.1021/jacs.2c04824. Epub 2022 Jul 5.
2
CF-PPiD technology based on cell-free protein array and proximity biotinylation enzyme for in vitro direct interactome analysis.基于无细胞蛋白质阵列和邻近生物素化酶的 CF-PPiD 技术用于体外直接互作组分析。
Sci Rep. 2022 Jun 22;12(1):10592. doi: 10.1038/s41598-022-14872-w.
3
Editorial: Genetics and Molecular Mechanisms of Oral and Esophageal Squamous Cell Carcinoma.社论：口腔和食管鳞状细胞癌的遗传学与分子机制
Front Oncol. 2022 Apr 6;12:874353. doi: 10.3389/fonc.2022.874353. eCollection 2022.
4
AURKA Increase the Chemosensitivity of Colon Cancer Cells to Oxaliplatin by Inhibiting the TP53-Mediated DNA Damage Response Genes.AURKA 通过抑制 TP53 介导的 DNA 损伤反应基因增加结肠癌细胞对奥沙利铂的化疗敏感性。
Biomed Res Int. 2020 Aug 10;2020:8916729. doi: 10.1155/2020/8916729. eCollection 2020.
5
Targeted therapies for non-HPV-related head and neck cancer: challenges and opportunities in the context of predictive, preventive, and personalized medicine.非HPV相关头颈癌的靶向治疗：预测、预防和个性化医学背景下的挑战与机遇
EPMA J. 2019 Jul 20;10(3):291-305. doi: 10.1007/s13167-019-00177-y. eCollection 2019 Sep.
6
A Network-guided Association Mapping Approach from DNA Methylation to Disease.基于 DNA 甲基化的网络导向关联映射方法研究疾病
Sci Rep. 2019 Apr 3;9(1):5601. doi: 10.1038/s41598-019-42010-6.
7
Identification of key candidate genes and pathways in hepatocellular carcinoma by integrated bioinformatical analysis.通过综合生物信息学分析鉴定肝细胞癌中的关键候选基因和信号通路
Exp Ther Med. 2018 Jun;15(6):4932-4942. doi: 10.3892/etm.2018.6075. Epub 2018 Apr 16.
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Functional Significance of Aurora Kinases-p53 Protein Family Interactions in Cancer.极光激酶-p53蛋白家族相互作用在癌症中的功能意义
Front Oncol. 2016 Nov 25;6:247. doi: 10.3389/fonc.2016.00247. eCollection 2016.
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Antitumor activity of the aurora a selective kinase inhibitor, alisertib, against preclinical models of colorectal cancer.极光A选择性激酶抑制剂阿利西替尼对结直肠癌临床前模型的抗肿瘤活性。
Oncotarget. 2016 Aug 2;7(31):50290-50301. doi: 10.18632/oncotarget.10366.
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Aurora Kinase A expression predicts platinum-resistance and adverse outcome in high-grade serous ovarian carcinoma patients.极光激酶A的表达可预测高级别浆液性卵巢癌患者的铂耐药性及不良预后。
J Ovarian Res. 2016 May 21;9(1):31. doi: 10.1186/s13048-016-0238-7.
本文引用的文献
1
Wild-type and mutated presenilins 2 trigger p53-dependent apoptosis and down-regulate presenilin 1 expression in HEK293 human cells and in murine neurons.野生型和突变型早老素2在人胚肾293细胞和小鼠神经元中引发p53依赖性凋亡并下调早老素1的表达。
Proc Natl Acad Sci U S A. 2002 Mar 19;99(6):4043-8. doi: 10.1073/pnas.062059899.
2
Aurora-A overexpression reveals tetraploidization as a major route to centrosome amplification in p53-/- cells.极光激酶A的过表达揭示了四倍体化是p53基因敲除细胞中中心体扩增的主要途径。
EMBO J. 2002 Feb 15;21(4):483-92. doi: 10.1093/emboj/21.4.483.
3
Difference in the centrosome duplication regulatory activity among p53 'hot spot' mutants: potential role of Ser 315 phosphorylation-dependent centrosome binding of p53.p53“热点”突变体之间中心体复制调控活性的差异：p53的Ser 315磷酸化依赖性中心体结合的潜在作用。
Oncogene. 2001 Oct 18;20(47):6851-63. doi: 10.1038/sj.onc.1204848.
4
Functional analysis and intracellular localization of p53 modified by SUMO-1.SUMO-1修饰的p53的功能分析及细胞内定位
Oncogene. 2001 May 3;20(20):2587-99. doi: 10.1038/sj.onc.1204362.
5
p53 displacement from centrosomes and p53-mediated G1 arrest following transient inhibition of the mitotic spindle.有丝分裂纺锤体短暂抑制后，p53从中心体移位及p53介导的G1期阻滞
J Biol Chem. 2001 Jun 1;276(22):19205-13. doi: 10.1074/jbc.M009528200. Epub 2001 Feb 28.
6
Nucleophosmin/B23 is a target of CDK2/cyclin E in centrosome duplication.核仁磷酸蛋白/B23是中心体复制过程中CDK2/细胞周期蛋白E的一个靶点。
Cell. 2000 Sep 29;103(1):127-40. doi: 10.1016/s0092-8674(00)00093-3.
7
A transactivation-deficient mouse model provides insights into Trp53 regulation and function.一种转录激活缺陷型小鼠模型为深入了解Trp53的调控和功能提供了线索。
Nat Genet. 2000 Sep;26(1):37-43. doi: 10.1038/79152.
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c-abl is involved in the association of p53 and trk A.c-abl参与p53与trk A的关联。
Oncogene. 2000 Jun 15;19(26):3032-40. doi: 10.1038/sj.onc.1203619.
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Antagonism between members of the CNC-bZIP family and the immediate-early protein IE2 of human cytomegalovirus.CNC-bZIP家族成员与人类巨细胞病毒即刻早期蛋白IE2之间的拮抗作用。
J Biol Chem. 2000 Apr 21;275(16):12313-20. doi: 10.1074/jbc.275.16.12313.
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p53 localizes to the centrosomes and spindles of mitotic cells in the embryonic chick epiblast, human cell lines, and a human primary culture: An immunofluorescence study.p53定位于胚胎鸡外胚层、人类细胞系和人类原代培养物中处于有丝分裂期细胞的中心体和纺锤体：一项免疫荧光研究。
Exp Cell Res. 2000 Apr 10;256(1):122-30. doi: 10.1006/excr.2000.4800.
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