Buchtel Henry A, Passaro Erasmo A, Selwa Linda M, Deveikis John, Gomez-Hassan Diana
Psychology Service, VA Ann Arbor Healthcare System, and Department of Psychiaty, University of Michigan, Ann Arbor, Michigan 48109-0840, USA.
Epilepsia. 2002 Sep;43(9):1056-61. doi: 10.1046/j.1528-1157.2002.00902.x.
We report our experience with sodium methohexital (Brevital) as an anesthetic used in the Wada test for language and memory in 86 epilepsy surgery patients (173 procedures).
The methods are compared with those of the more commonly used anesthetic sodium amobarbital (Amytal).
Despite differences between the methohexital and amobarbital test protocols, the behavioral and neurologic effects of the two anesthetics are similar. Because of the brief duration of methohexital, two successive injections are made on each side rather than one, to lengthen the time available for testing both language and memory. Behavioral and EEG indices return to baseline more quickly and more completely with methohexital than with amobarbital, allowing several repetitions of the procedure without incremental drowsiness, and the total time taken for the procedure is less with methohexital than with amobarbital.
The results of language and memory testing in the Wada test are equivalent for amobarbital and methohexital, except that methohexital has a briefer duration of action and is associated with less sedation.
我们报告了在86例癫痫手术患者（173例手术）的Wada试验中使用甲己炔巴比妥钠（布雷维新）作为语言和记忆麻醉剂的经验。
将这些方法与更常用的麻醉剂戊巴比妥钠（阿米妥）的方法进行比较。
尽管甲己炔巴比妥钠和戊巴比妥钠试验方案存在差异，但两种麻醉剂的行为和神经学效应相似。由于甲己炔巴比妥钠作用时间短暂，每侧需连续注射两次而非一次，以延长测试语言和记忆的可用时间。与戊巴比妥钠相比，甲己炔巴比妥钠作用后行为和脑电图指标恢复到基线更快、更完全，允许该操作重复进行而不会增加嗜睡，且甲己炔巴比妥钠进行该操作所需的总时间比戊巴比妥钠少。
在Wada试验中，戊巴比妥钠和甲己炔巴比妥钠的语言和记忆测试结果相当，只是甲己炔巴比妥钠的作用持续时间较短且镇静作用较小。
