黑猩猩淋巴细胞与高度致敏的潜在肾移植受者血清之间的交叉配型结果。
Results of crossmatch between chimpanzee lymphocytes and sera of highly sensitized potential renal transplant recipients.
作者信息
Rabkin David G, Nowygrod Roman, Hardy Mark A, Reemtsma Keith
机构信息
Department of Surgery, Presbyterian Hospital of New York, Columbia-Presbyterian Medical Center, New York, NY, USA.
出版信息
Xenotransplantation. 2002 Sep;9(5):359-62. doi: 10.1034/j.1399-3089.2002.01108.x.
BACKGROUND
We tested the hypothesis that patients with a high frequency of lymphocytotoxic antibodies against human cells are not highly sensitized to major histocompatibility complexes expressed by chimpanzee cells.
METHODS
Sera from six "hopelessly" sensitized patients (percentage reactive antibodies (PRA) > 99%) on the renal transplant waiting list were crossmatched with peripheral blood lymphocytes from 10 chimpanzees. Lymphocytotoxic antibodies reacting with chimpanzee peripheral blood lymphocytes were identified.
RESULTS
Three of the six patients with a high frequency of lymphocytotoxic antibodies against human cells had no xenospecific antibodies.
CONCLUSION
Patients with a high frequency of lymphocytotoxic antibodies against human cells are not all panel-reactive to chimpanzees. Unilateral donor nephrectomy in non-human primates may offer an opportunity for safe expansion of the donor organ pool for these patients.
背景
我们检验了以下假设，即针对人类细胞的淋巴细胞毒性抗体频率较高的患者，对黑猩猩细胞表达的主要组织相容性复合体不具有高度敏感性。
方法
对肾移植等待名单上6名“极度”致敏患者（反应性抗体百分比（PRA）>99%）的血清与10只黑猩猩的外周血淋巴细胞进行交叉配型。鉴定与黑猩猩外周血淋巴细胞发生反应的淋巴细胞毒性抗体。
结果
6名针对人类细胞的淋巴细胞毒性抗体频率较高的患者中，有3名没有异种特异性抗体。
结论
针对人类细胞的淋巴细胞毒性抗体频率较高的患者并非都对黑猩猩有群体反应性。对非人灵长类动物进行单侧供体肾切除术可能为这些患者安全扩大供体器官库提供机会。
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