用雾化结核分枝杆菌感染小鼠：使用仅经鼻装置递送低剂量接种物及超安全设施的设计
Infection of mice with aerosolized Mycobacterium tuberculosis: use of a nose-only apparatus for delivery of low doses of inocula and design of an ultrasafe facility.
作者信息
Schwebach J Reid, Chen Bing, Glatman-Freedman Aharona, Casadevall Arturo, McKinney John D, Harb John L, McGuire Patrick J, Barkley W Emmett, Bloom Barry R, Jacobs William R
机构信息
Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York 10461, USA.
出版信息
Appl Environ Microbiol. 2002 Sep;68(9):4646-9. doi: 10.1128/AEM.68.9.4646-4649.2002.
Abstract
Aerosolized delivery of virulent or hypervirulent Mycobacterium tuberculosis requires careful consideration of methodology and safety. To maximize safety, we installed a nose-only aerosol apparatus that can reproducibly deliver a low dose (<100 CFU per mouse) of M. tuberculosis in a carefully designed biohazard facility.
摘要
对强毒或超强毒结核分枝杆菌进行雾化给药需要仔细考虑方法和安全性。为了最大限度地提高安全性，我们安装了一种仅用于鼻腔的雾化装置，该装置能够在精心设计的生物危害设施中，以可重复的方式给小鼠递送低剂量（每只小鼠<100 CFU）的结核分枝杆菌。
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