Tsapis N, Bennett D, Jackson B, Weitz D A, Edwards D A
Department of Physics, and Division of Engineering and Applied Sciences, Harvard University, 9 Oxford Street, Cambridge, MA 02138, USA.
Proc Natl Acad Sci U S A. 2002 Sep 17;99(19):12001-5. doi: 10.1073/pnas.182233999. Epub 2002 Aug 28.
We have combined the drug release and delivery potential of nanoparticle (NP) systems with the ease of flow, processing, and aerosolization potential of large porous particle (LPP) systems by spray drying solutions of polymeric and nonpolymeric NPs into extremely thin-walled macroscale structures. These hybrid LPPs exhibit much better flow and aerosolization properties than the NPs; yet, unlike the LPPs, which dissolve in physiological conditions to produce molecular constituents, the hybrid LPPs dissolve to produce NPs, with the drug release and delivery advantages associated with NP delivery systems. Formation of the large porous NP (LPNP) aggregates occurs via a spray-drying process that ensures the drying time of the sprayed droplet is sufficiently shorter than the characteristic time for redistribution of NPs by diffusion within the drying droplet, implying a local Peclet number much greater than unity. Additional control over LPNPs physical characteristics is achieved by adding other components to the spray-dried solutions, including sugars, lipids, polymers, and proteins. The ability to produce LPNPs appears to be largely independent of molecular component type as well as the size or chemical nature of the NPs.
我们通过将聚合物纳米颗粒（NP）和非聚合物纳米颗粒的溶液喷雾干燥成极薄壁的宏观结构，将纳米颗粒（NP）系统的药物释放和递送潜力与大孔颗粒（LPP）系统的易流动、易加工及气溶胶化潜力结合起来。这些混合LPPs表现出比NP更好的流动和气溶胶化特性；然而与在生理条件下溶解以产生分子成分的LPPs不同，混合LPPs溶解后产生NP，具有NP递送系统相关的药物释放和递送优势。大孔纳米颗粒（LPNP）聚集体的形成是通过喷雾干燥过程实现 的，该过程确保喷雾液滴的干燥时间比NP在干燥液滴内通过扩散重新分布的特征时间足够短，这意味着局部佩克莱数远大于1。通过向喷雾干燥溶液中添加其他成分（包括糖、脂质、聚合物和蛋白质），可以进一步控制LPNP的物理特性。产生LPNP 的能力似乎在很大程度上与分子成分类型以及NP的大小或化学性质无关。
