Kawaguchi H, Koiwai N, Ohtsuka Y, Miyamoto M, Sasakawa S
Biomaterials. 1986 Jan;7(1):61-6. doi: 10.1016/0142-9612(86)90091-8.
A series of latex particles, having different sizes and surface structures, were prepared and the dependence of phagocytosis of latex particles by leucocytes on the particle size and surface potential was investigated by measuring the oxygen consumption of leucocytes. Most of the phagocytic behaviour in the initial stages can be explained by susceptibility of particles to heterocoagulation i.e. attachment of small particles (latex particles) onto large particles (leucocytes) by the colloidal attractive force between the two kinds of particles. Specific behaviour for fine particles seems to be attributed to the contribution of steric stabilization by the hydrated layer on the particle surface and to the inability for the leucocytes to recognize very fine particles as foreign materials.
制备了一系列具有不同尺寸和表面结构的乳胶颗粒，并通过测量白细胞的耗氧量，研究了白细胞对乳胶颗粒的吞噬作用与颗粒大小和表面电位的关系。初始阶段的大多数吞噬行为可以用颗粒对异质凝聚的敏感性来解释，即小颗粒（乳胶颗粒）通过两种颗粒之间的胶体吸引力附着在大颗粒（白细胞）上。细颗粒的特殊行为似乎归因于颗粒表面水合层的空间稳定作用，以及白细胞无法将非常细的颗粒识别为外来物质。
