通过多种方法对抗疟药物（±）-氯喹进行氚标记及表征。
Tritium labelling and characterization of the antimalarial drug (+/-)-chloroquine by several methods.
作者信息
Egan Judith A, Laseter Anne G, Filer Crist N
机构信息
PerkinElmer Life Sciences, Inc., 549 Albany St., Boston, MA 02118, USA.
出版信息
Appl Radiat Isot. 2002 Sep;57(3):343-5. doi: 10.1016/s0969-8043(02)00117-3.
Abstract
To study its mechanism of antimalarial action, a tritium labelled analogue of (+/-)-chloroquine was required at high specific activity. Two synthetic methods were successfully employed. [3-3H] (+/-)-Chloroquine 2 was prepared by the catalytic tritium dehalogenation of an iodo precursor and [N-ethyl-3H] (+/-)-chloroquine 4 was synthesized by the alkylation of (+/-)-desethylchloroquine with [3H] ethyl iodide.
摘要
为研究其抗疟作用机制，需要高比活度的氚标记的（±）-氯喹类似物。成功采用了两种合成方法。[3-³H]（±）-氯喹2是通过碘代前体的催化氚脱卤制备的，[N-乙基-³H]（±）-氯喹4是通过（±）-去乙基氯喹与[³H]碘乙烷的烷基化反应合成的。
Zotero 插件