Bari M E, Forster D M C, Kemeny A A, Walton L, Hardy D, Anderson J R
Department of Neurosurgery, Royal Hallamshire Hospital, Sheffield, UK.
Br J Neurosurg. 2002 Jun;16(3):284-9. doi: 10.1080/02688690220148888.
Malignant change in schwannoma is rare. Malignant change in a vestibular schwannoma (acoustic neuroma) is even more rare. This paper presents a case of rapidly growing vestibular schwannoma first treated by radiosurgery whose histopathology after surgical excision 42 months later showed malignant changes. Up to now, eight cases of malignancy in eighth nerve tumours have been reported, four of which, including the present case, had previously been treated with radiosurgery and four cases that had not received radiation. Thus, it would seem, the overall incidence is extremely low. Nevertheless, extreme vigilance and careful reporting continues to be necessary.
神经鞘瘤发生恶变很罕见。前庭神经鞘瘤（听神经瘤）发生恶变则更为罕见。本文报告了一例生长迅速的前庭神经鞘瘤，最初接受了放射外科治疗，42个月后手术切除的组织病理学检查显示发生了恶变。截至目前，已报道了8例第八神经肿瘤恶变的病例，其中4例，包括本病例，此前接受过放射外科治疗，另外4例未接受过放疗。因此，总体发病率似乎极低。然而，仍需保持高度警惕并仔细报告。
