Alvarado Maria C, Wright Anthony A, Bachevalier Jocelyne
Department of Neurobiology and Anatomy, University of Texas Health Science Center at Houston, 77030, USA.
Hippocampus. 2002;12(4):421-33. doi: 10.1002/hipo.1115.
Adult rhesus monkeys with neonatal aspiration lesions of the hippocampal formation or the amygdaloid complex (including their respective subjacent cortices) and their age-matched controls were tested on the transverse patterning problem (A+ vs. B-, B+ vs. C- and C+ vs. A-) and a spatial version of the delayed nonmatching-to-sample (DNMS) task with delays of 10 s to 30 s, 60 s, 120 s, and 600 s. Monkeys with neonatal damage to the amygdaloid complex learned both tasks and did not differ from controls at any delay of the spatial DNMS task. Monkeys with neonatal hippocampal damage, however, were unable to learn transverse patterning, though they easily transferred to a linear series (A+ vs. B-, B+ vs. C-, and C+ vs. X-). Three of the four were also unable to reach criterion on the spatial DNMS task within the limits of testing, and the performance of all four monkeys deteriorated with increasing choice delays. The data suggest a role of the primate hippocampal region in both object and spatial relational learning.
对患有海马结构或杏仁核复合体（包括其下方相应皮质）新生儿期吸入性损伤的成年恒河猴及其年龄匹配的对照组，进行了横向模式问题（A+对B-、B+对C-以及C+对A-）和延迟10秒至30秒、60秒、120秒及600秒的空间版本延迟非匹配样本（DNMS）任务测试。杏仁核复合体有新生儿期损伤的猴子学会了这两项任务，并且在空间DNMS任务的任何延迟情况下与对照组均无差异。然而，有新生儿期海马损伤的猴子虽然能轻松转移到线性序列（A+对B-、B+对C-以及C+对X-），却无法学会横向模式。四只猴子中有三只在测试范围内也未能在空间DNMS任务中达到标准，并且所有四只猴子的表现都随着选择延迟的增加而变差。数据表明灵长类海马区在物体和空间关系学习中均发挥作用。
