Revell Jefferson D, Ganesan A
Combinatorial Centre of Excellence, Department of Chemistry, University of Southampton, United Kingdom.
Org Lett. 2002 Sep 5;4(18):3071-3. doi: 10.1021/ol0263292.
[reaction: see text] Room-temperature ionic liquids promote various transition metal-catalyzed reactions in the solution phase. Here, for the first time, we show that these effects are translatable to solid-phase reactions. The Suzuki-Miyaura cross-coupling of 4-iodophenol immobilized on polystyrene-Wang resin with various arylboronic acids was significantly accelerated by the ionic liquid 1-butyl-3-methylimidazolium tetrafluoroborate ([bmim][BF(4)(-)]).
