van der Wal Jacqueline E, Becking Alfred G, Snow Gordon B, van der Waal Isaac
Department of Oral & Maxillofacial Surgery/Oral Pathology, VU Medical Centre, P.O. Box 7057, 1007 MB Amsterdam, The Netherlands.
Head Neck. 2002 Aug;24(8):779-83. doi: 10.1002/hed.10126.
Adenoid cystic carcinoma (ACC) accounts for approximately 10% of all neoplasms of the salivary glands. Late distant metastases and local recurrences are responsible for a rather low long-term survival rate.
To study the metastasizing pattern of ACC of the salivary glands in 51 patients.
Fifty-one patients with an ACC in the intraoral/sublingual salivary glands (n = 30), parotid gland (n = 8), submandibular gland (n = 2), maxillary sinus (n = 6), and nasal cavity (n = 5) have been studied. The male-female ratio was 1:1, the mean age was 54.3 (range, 19-81) years. In 30 cases treatment consisted of surgery and radiotherapy. In 13 cases surgery alone was carried out. The average follow-up time was 117.8 (range, 1-171) months.
In 28 cases (54.9%) distant metastases occurred, and in 3 patients (5.8%) regional lymph node metastases occurred. In 12 of the 28 patients with distant metastases (42.8%), only the lungs were involved, whereas in 5 of the 28 patients (17.8%), the distant metastases occurred in other organs (eg, bones and brain). In 11 of the 28 patients (39.2%) metastases were found both in the lungs and other organs. Twenty-four of the 51 patients (47.0%) died because of their tumor. The average time between the occurrence of lung metastases and death was 32.3 months and between the occurrence of metastases elsewhere and death 20.6 months.
Distant metastases of ACC of the salivary glands occur most often in the lungs. Although these lung metastases are the first to occur, these patients die later than patients with distant metastases in other organs. The value of annual chest films or other tests for the presence of distant metastases during follow-up after surgical removal of an ACC seems rather questionable.
腺样囊性癌（ACC）约占涎腺所有肿瘤的10%。晚期远处转移和局部复发导致长期生存率相当低。
研究51例涎腺腺样囊性癌的转移模式。
对51例口腔内/舌下涎腺（n = 30）、腮腺（n = 8）、下颌下腺（n = 2）、上颌窦（n = 6）和鼻腔（n = 5）发生腺样囊性癌的患者进行了研究。男女比例为1:1，平均年龄为54.3岁（范围19 - 81岁）。30例患者接受了手术和放疗。13例患者仅接受了手术。平均随访时间为117.8个月（范围1 - 171个月）。
28例（54.9%）发生远处转移，3例（5.8%）发生区域淋巴结转移。28例发生远处转移的患者中，12例（42.8%）仅肺部受累，而28例患者中的5例（17.8%）远处转移发生在其他器官（如骨骼和脑）。28例患者中的11例（39.2%）肺部和其他器官均发现转移。51例患者中有24例（47.0%）因肿瘤死亡。肺转移发生至死亡的平均时间为32.3个月，其他部位转移发生至死亡的平均时间为20.6个月。
涎腺腺样囊性癌远处转移最常发生于肺部。虽然这些肺转移是最先发生的，但这些患者比其他器官发生远处转移的患者死亡时间更晚。在手术切除腺样囊性癌后随访期间，每年进行胸部X线片或其他检查以发现远处转移的价值似乎相当可疑。
