麻醉剂量的一氧化碳可诱导绵羊神经元中的血红素加氧酶和一氧化氮合酶。
A narcotic dose of carbon monoxide induces neuronal haeme oxygenase and nitric oxide synthetase in sheep.
作者信息
Gorman Des, Huang Y L, Williams Chris
机构信息
Liggins Institute, University of Auckland, Private Bag 92019, Auckland, New Zealand.
出版信息
Toxicology. 2002 Sep 30;179(1-2):79-84. doi: 10.1016/s0300-483x(02)00339-6.
Twelve Romney ewes were exposed to either 1% carbon monoxide (CO) in air (n=6) or room air alone for 120 min and were killed 15 days later for histological and immunohistochemical examination. This dose of CO was narcotic and induced both haeme oxygenase and nitric oxide synthetase in brain neurons, but not in endothelial cells. The mechanism of the induction is not established here, but cellular theories of CO toxicity will need to be re-examined given these results.
12只罗姆尼母羊分别暴露于含1%一氧化碳（CO）的空气中（n = 6）或仅暴露于室内空气中120分钟，15天后处死进行组织学和免疫组织化学检查。该剂量的CO具有麻醉作用，可诱导脑神经元中的血红素加氧酶和一氧化氮合酶，但不能诱导内皮细胞中的这些酶。本文未确定诱导机制，但鉴于这些结果，需要重新审视CO毒性的细胞理论。
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