Liu F Y, Duan S B, Peng Y M
Department of Medicine, Second Affiliated Hospital, Hunan Medical University, Changsha 410011.
Hunan Yi Ke Da Xue Xue Bao. 2000 Aug 28;25(4):347-50.
To investigate whether the small solutes transport and the efficiency of peritoneal dialysis can be improved through ventral movement.
Eighteen continuous ambulatory peritoneal dialysis (CAPD) patients and 6 male New Zealand rabbits peritoneal dialysis models were observed. Through self and pre-post control, we compared the concentration ratio of the solutes in effluent dialyste(D) to the solutes in plasma(P), mass transfer area coefficient and the drained volume.
The animal experiments showed that the D/P value for BUN was different prominently when comparing the vibration and non-vibration groups in 45 min and 60 min separately(P < 0.05). On the contrary, no obvious difference existed between the two groups when comparing the D/P values for protein and drained volume. The clinical study showed: D/P value for BUN at the 2 and 4 hr and D/P value for creatinine at the 2 hr increased obviously either in the low or high frequency group when compared with the control group(P < 0.01, P < 0.01, P < 0.05, respectively). D/P for protein and drained volume had no difference compared with the control group(P > 0.05).
The ventral movement and vibration could efficiently increase the transport of small solutes such as BUN and creatinine while had no influence on the transport of large molecular solutes such as protein and the ultrafiltration volume. It suggested that increasing the movement of CAPD patients can improve the efficiency of peritoneal dialysis.
探讨通过腹部运动是否能改善小分子溶质转运及腹膜透析效率。
观察18例持续性非卧床腹膜透析（CAPD）患者及6只雄性新西兰兔腹膜透析模型。通过自身前后对照，比较透析液（D）中溶质与血浆（P）中溶质的浓度比、传质面积系数及引流液量。
动物实验显示，分别比较45分钟和60分钟时振动组与非振动组，血尿素氮（BUN）的D/P值有显著差异（P<0.05）。相反，比较两组蛋白质的D/P值及引流液量时，两组间无明显差异。临床研究显示：与对照组相比，低频组和高频组在2小时和4小时时BUN的D/P值以及2小时时肌酐的D/P值均明显升高（分别为P<0.01、P<0.01、P<0.05）。蛋白质的D/P值及引流液量与对照组相比无差异（P>0.05）。
腹部运动及振动可有效增加BUN和肌酐等小分子溶质的转运，而对蛋白质等大分子溶质的转运及超滤量无影响。提示增加CAPD患者的活动可提高腹膜透析效率。
