Pichot P
Arch Psychiatr Nervenkr (1970). 1975 Dec 22;220(4):281-8. doi: 10.1007/BF00342058.
The paper discusses the general methodologic aspects of therapeutic trials in psychopharmacology under three main headings: definition of the concepts of disease, treatment, and healing. In each case, the author discusses the main difficulties, and gives concrete examples. In conclusions, the complexity of the methodologic problems is stressed, but the author considers that the cost of using correct experimental designs is more than balanced by the safety of the statistical conclusions.
疾病、治疗和治愈概念的定义。在每种情况下，作者都讨论了主要困难，并给出了具体例子。在结论中，强调了方法学问题的复杂性，但作者认为，使用正确实验设计的成本与统计结论的安全性相比是绰绰有余的。
