Solti F, Jahász-Nagy A
Basic Res Cardiol. 1975 Nov-Dec;70(6):639-46. doi: 10.1007/BF01906473.
The carotid sinus nerves of dogs were electrically stimulated to reveal reflex effects exerted on the coronary blood flow both in normal and ischaemic states. Myocardia ischaemia was produced by occlusion of the left anterior descending (LAD) coronary artery. In 10 experiments the coronary sinus outflow was measured as an index of the overall coronary flow; in 30 cases the local myocardial blood flow was registered by means of the heat clearance technique. In the overall coronary flow carotid sinus nerve stimulation (CSNS) elicited coronary dilatation. After acute LAD occlusion this effect was slightly potentiated. A similar but significantly greater potentiation was observed in the local reflex vascular dilatation recorded with the aid of the thermal probes immediately after LAD occlusion when the myocardial area explored was supplied exclusively by collateral channels. 24-48 hours and 5-64 days after the coronary ligation the effect of the CSNS on the local blood flow was tested in the developing and the regenerative phases of the myocardial infarction. In both phases an enhanced reflex dilatation was found in the collateral-dependent ischaemic areas as compared to the myocardial areas supplied by the normal vessels. The results suggest that reflexly induced intrinsic redistribution of the myocardial blood flow is one of the mechanisms responsible for the therapeutical effects of the CSNS.
电刺激犬的颈动脉窦神经，以揭示在正常和缺血状态下对冠状动脉血流产生的反射效应。通过闭塞左前降支（LAD）冠状动脉造成心肌缺血。在10个实验中，测量冠状窦血流量作为总体冠状动脉血流的指标；在30个病例中，采用热清除技术记录局部心肌血流量。在总体冠状动脉血流中，颈动脉窦神经刺激（CSNS）引起冠状动脉扩张。急性LAD闭塞后，这种效应略有增强。在LAD闭塞后立即借助热探针记录的局部反射性血管扩张中，当所探查的心肌区域仅由侧支循环供血时，观察到类似但明显更强的增强作用。在冠状动脉结扎后的24 - 48小时以及5 - 64天，在心肌梗死的发展期和再生期测试CSNS对局部血流的影响。在两个阶段中，与由正常血管供血的心肌区域相比，在依赖侧支循环的缺血区域发现反射性扩张增强。结果表明，反射性诱导的心肌血流内在重新分布是CSNS治疗作用的机制之一。
