[Pemphigus induced by D-penicillamine in rheumatoid arthritis. Study of 5 cases and systematic study of anti-intercellular substance antibodies of the skin in the course of treatment].

The authors present 5 cases of pemphigus induced by D-penicillamine in a series of 180 cases of rheumatoid arthritis treated with this medication. In addition, anti-epidermal intercellular substance antibodies were sought in 40 asymptomatic patients. No antibodies were found in this group. The notion of induced pemphigus seems well established, as is the value of testing for antibodies in the surveillance of D-penicillamine treatment.