No association between the neuronal nitric oxide synthase gene polymorphism and Alzheimer Disease.
作者信息
Liou Ying-Jay, Hong Chen-Jee, Liu Hsiu-Chih, Liu Chia-Yih, Liu Tsung-Yun, Chen I-Chun, Tsai Shih-Jen
机构信息
Section of Psychiatry, Yu-Li Veterans Hospital, Hualien, Taiwan, Republic of China.
出版信息
Am J Med Genet. 2002 Aug 8;114(6):687-8. doi: 10.1002/ajmg.10670.
PMID:12210288
Abstract
Nitric oxide synthase (NOS) has been implicated in the pathogenesis of Alzheimer disease (AD). To examine the role of the neuronal NOS (nNOS) gene in AD, patients (n = 139) and control subjects (n = 101) were genotyped for the nNOS dinucleotide polymorphism. No association was demonstrated for AD and this particular nNOS polymorphism.
摘要
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