Heesterbeek J A P
Faculty of Veterinary Medicine, University of Utrecht, Quantitative Veterinary Epidemiology Group, The Netherlands.
Acta Biotheor. 2002;50(3):189-204. doi: 10.1023/a:1016599411804.
In this paper I present the genesis of R0 in demography, ecology and epidemiology, from embryo to its current adult form. I argue on why it has taken so long for the concept to mature in epidemiology when there were ample opportunities for cross-fertilisation from demography and ecology from where it reached adulthood fifty years earlier. Today, R0 is a more fully developed adult in epidemiology than in demography. In the final section I give an algorithm for its calculation in heterogeneous populations.
在本文中，我阐述了繁殖数（R0）在人口统计学、生态学和流行病学中的起源，从其雏形到当前的成熟形式。我探讨了为何在有充分机会从人口统计学和生态学中进行交叉借鉴的情况下，繁殖数（R0）这一概念在流行病学中花了如此长的时间才成熟，而它在人口统计学和生态学中早在五十年前就已成熟。如今，繁殖数（R0）在流行病学中比在人口统计学中发展得更为成熟。在最后一部分，我给出了在异质人群中计算繁殖数（R0）的算法。
