安搏律定对几种类型室性心律失常的抗心律失常作用。

Antiarrhythmic effect of aprindine on several types of ventricular arrhythmias.

作者信息

Ueda M, Kimoto S, Matsuda S, Kawakami M, Mroishige E, Matsumura S, Takeda H

出版信息

Jpn J Pharmacol. 1975 Oct;25(5):549-61. doi: 10.1254/jjp.25.549.

DOI:10.1254/jjp.25.549

Abstract

The antiarrhythmic effect of aprindine was compared with those of lidocaine and propranolol on several ventricular arrhythmias-epinephrine arrhythmias in cats, ouabain arrhythmias in cats and guinea pigs, ischemic ventricular arrhythmias in coronary-ligated Beagle dogs. Antiarrhythmic effects of aprindine and lidocaine were observed both in ouagain and ischemic arrhythmias, but not in epinephrine arrhythmias. While propranolol had a strong antiarrhythmic effect against epinephrine and ouabain arrhythmias, it did not increase sinus beats in ischemic arrhythmias. Marked anti-arrhythmic effects of aprindine in ischemic arrhythmias were observed in dogs using either single intravenous administration (4 mg/kg) or intravenous infusion (200 mug/kg/min, 2 mg/kg). Antiarrhythmic activity of aprindine is considered to be about twice as strong as that of lidocaine, but lidocaine is less toxic in experimental animals.

摘要

将安搏律定的抗心律失常作用与利多卡因和普萘洛尔对几种室性心律失常（猫的肾上腺素性心律失常、猫和豚鼠的哇巴因性心律失常、冠状动脉结扎的比格犬的缺血性室性心律失常）的作用进行了比较。在哇巴因性和缺血性心律失常中均观察到了安搏律定和利多卡因的抗心律失常作用，但在肾上腺素性心律失常中未观察到。虽然普萘洛尔对肾上腺素性和哇巴因性心律失常有很强的抗心律失常作用，但在缺血性心律失常中它并未增加窦性心律。在犬中，无论是单次静脉注射（4mg/kg）还是静脉输注（200μg/kg/min，2mg/kg），均观察到安搏律定对缺血性心律失常有明显的抗心律失常作用。安搏律定的抗心律失常活性被认为约为利多卡因的两倍，但利多卡因在实验动物中的毒性较小。