Ferro G, Chiariello M, Tari M G, Vigorito C, Ungaro B, Condorelli M
Jpn Heart J. 1983 May;24(3):377-90. doi: 10.1536/ihj.24.377.
The effects of intravenous administration of several quinidine-like antiarrhythmic drugs (bunaftine, monochloroacetyl ajmaline, lidocaine, mexiletine, disopyramide, aprindine, diphenylhydantoin, procainamide) on left ventricular performance, evaluated by systolic time intervals (STI), were studied in 100 patients with atherosclerotic heart disease. The STI were measured: the pre-ejection period (PEP), the isometric contraction time (ICT), the left ventricular ejection time (LVET), corrected LVET (LVETc), and the PEP/LVET ratio. The degree of impairment of left ventricular performance was maximal after aprindine and disopyramide administration. This was demonstrated by significant increases in the PEP, ICT, and PEP/LVET and by significant decreases in LVET and LVETc, in patients in both III-IV and I-II NYHA classes. Bunaftine, monochloroacetyl ajmaline, and lidocaine induced a less marked impairment of myocardial performance, since the PEP, ICT, and PEP/LVET increases were not significant compared to controls in patients in NYHA class I-II, and since no variation of LVET and LVETc were observed. Mexiletine effects on myocardial performance appear to be intermediate between these groups of drugs. Diphenylhydantoin and procainamide, considered separately because of their effects on heart rate and blood pressure which are not possessed by the other drugs, induced significant increases of PEP in NYHA class III-IV patients. However, the effects of these 2 drugs on myocardial performance may have been underestimated, due to the concomitant hemodynamic effect of these drugs.
在100例动脉粥样硬化性心脏病患者中，研究了静脉注射几种奎尼丁样抗心律失常药物（布萘呋汀、单氯乙酰阿马林、利多卡因、美西律、丙吡胺、阿普林定、苯妥英钠、普鲁卡因胺）对通过收缩期时间间期（STI）评估的左心室功能的影响。测量了STI：射血前期（PEP）、等容收缩时间（ICT）、左心室射血时间（LVET）、校正后的LVET（LVETc）以及PEP/LVET比值。在给予阿普林定和丙吡胺后，左心室功能损害程度最大。这在III-IV级和I-II级纽约心脏协会（NYHA）分级的患者中表现为PEP、ICT和PEP/LVET显著增加，LVET和LVETc显著降低。布萘呋汀、单氯乙酰阿马林和利多卡因引起的心肌功能损害较轻，因为在I-II级NYHA分级的患者中，与对照组相比，PEP、ICT和PEP/LVET的增加不显著，且未观察到LVET和LVETc的变化。美西律对心肌功能的影响似乎介于这些药物组之间。苯妥英钠和普鲁卡因胺因其对心率和血压的影响（其他药物不具备）而单独考虑，在III-IV级NYHA分级的患者中引起PEP显著增加。然而，由于这些药物的伴随血流动力学效应，这两种药物对心肌功能的影响可能被低估了。
