[奈法唑酮治疗中出现急性肝衰竭？一例报告]

[Acute liver failure in nefazodone therapy? A case report].

作者信息

Ehrentraut S, Rothenhäusler H B, Gerbes A L, Rau H G, Thiel M, Schirren C A, Kapfhammer H P

机构信息

Psychiatrische Klinik und Poliklinik der LMU München, Nussbaumstrasse 7, 80336 München.

出版信息

Nervenarzt. 2002 Jul;73(7):686-9. doi: 10.1007/s00115-002-1350-z.

DOI:10.1007/s00115-002-1350-z

PMID:12212533

Abstract

Antidepressant-induced hepatotoxicity is generally considered of minimal clinical importance and is not well recognized. We report on a patient with recurrent major depression who was treated with nefazodone. Six weeks after initiation of therapy with nefazodone, he developed fatal liver failure. After cessation of the drug, the patient did not recover. He underwent liver transplantation but unfortunately died.

摘要

抗抑郁药引起的肝毒性通常被认为临床重要性极小，且未得到充分认识。我们报告一例复发性重度抑郁症患者，其接受了奈法唑酮治疗。在开始使用奈法唑酮治疗六周后，他出现了致命的肝衰竭。停药后，患者未能康复。他接受了肝移植，但不幸去世。