Zhao Ning, Gootman Phyllis M, Sica Anthony L
Department of Physiology and Pharmacology, SUNY Downstate Medical Center, Box 31, 450 Clarkson Avenue, Brooklyn, NY 11203, USA.
Neurosci Lett. 2002 Sep 13;330(1):79-83. doi: 10.1016/s0304-3940(02)00687-0.
This study was carried out to determine whether selective cardiac autonomic denervation performed on neonatal swine would evoke dysrhythmias later in development. Piglets (n = 27; 5-10 days old) underwent unilateral stellate ganglion ablation, or right cardiac vagotomy, or sham surgery. Fifty to sixty days after denervation, acute experiments were performed to evaluate responses to baroreceptor activation. Of all animals who exhibited prolonged R-R intervals, only those with right stellate ganglion ablation had prolonged corrected QT intervals. Despite findings suggesting an arrhythmogenic state (predominance of left-sided cardiac innervation), dysrhythmias occurred in all animals with stellate ganglion ablation, regardless of laterality, but in few vagotomized or control animals. Our results suggest that partial sympathetic innervation may alter cardiac function so that dysrhythmias are more likely to occur during baroreceptor activation.
本研究旨在确定对新生猪进行选择性心脏自主神经去神经支配是否会在发育后期引发心律失常。仔猪（n = 27；5 - 10日龄）接受单侧星状神经节切除术、右侧心脏迷走神经切断术或假手术。去神经支配后50至60天，进行急性实验以评估对压力感受器激活的反应。在所有表现出R-R间期延长的动物中，只有右侧星状神经节切除的动物校正QT间期延长。尽管研究结果提示存在致心律失常状态（左侧心脏神经支配占主导），但星状神经节切除的所有动物均出现心律失常，无论其切除侧别如何，而迷走神经切断或对照动物中很少出现心律失常。我们的结果表明，部分交感神经支配可能会改变心脏功能，从而使在压力感受器激活期间更易发生心律失常。
