基于4666个微卫星标记对HLA-DRB1*15阳性的德国多发性硬化症患者进行连锁不平衡的全基因组筛查。
A genome screen for linkage disequilibrium in HLA-DRB1*15-positive Germans with multiple sclerosis based on 4666 microsatellite markers.
作者信息
Goedde Rene, Sawcer Stephen, Boehringer Stefan, Miterski Bianca, Sindern Eckhart, Haupts Michael, Schimrigk Sebastian, Compston Alastair, Epplen Joerg T
机构信息
Department of Molecular Human Genetics, Ruhr-University, Universitätsstrasse 150, 44780 Bochum, Germany.
出版信息
Hum Genet. 2002 Sep;111(3):270-7. doi: 10.1007/s00439-002-0801-8. Epub 2002 Jul 31.
Multiple sclerosis (MS) is a demyelinating disorder of the central nervous system with putative autoimmune aetiology and complex genetic background. Here, we report the results of a genome screen for linkage disequilibrium (LD) by using 6000 microsatellite markers in 198 HLA-DRB1*15-positive MS patients and 198 unrelated controls (pooled DNA); 4666 analysed markers could be included in the resulting association map, from which 87 revealed significant differences between MS cases and controls.
多发性硬化症（MS）是一种中枢神经系统脱髓鞘疾病，具有假定的自身免疫病因和复杂的遗传背景。在此，我们报告了一项基因组筛查结果，该筛查通过在198例HLA-DRB1*15阳性的MS患者和198名无关对照（混合DNA）中使用6000个微卫星标记来检测连锁不平衡（LD）；4666个分析标记可纳入最终的关联图谱，其中87个显示MS病例与对照之间存在显著差异。
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