系统性红斑狼疮患者行Tc-99m ECD脑单光子发射计算机断层扫描时局部脑血流异常的客观证据。

Objective evidence of abnormal regional cerebral blood flow in patients with systemic lupus erythematosus on Tc-99m ECD brain SPECT.

作者信息

Huang W S, Chiu P Y, Tsai C H, Kao A, Lee C C

机构信息

Department of Neurology, China Medical College Hospital, Taichung, Taiwan.

出版信息

Rheumatol Int. 2002 Sep;22(5):178-81. doi: 10.1007/s00296-002-0224-9. Epub 2002 Jul 27.

DOI:10.1007/s00296-002-0224-9

PMID:12215861

Abstract

Technetium-99m ethyl cysteinate dimer (Tc-99m ECD) brain single photon emission computed tomography (SPECT) was used to detect abnormal regional cerebral blood flow (rCBF) in 78 SLE patients with neuropsychiatric manifestations. These patients were separated into two subgroups: group 1 including 48 cases with definite neuropsychiatric symptoms/signs and group 2 with 30 cases having no neuropsychiatric symptoms/signs. Tc-99m ECD brain SPECT demonstrated hypoperfusion brain lesions in 90% and 20% of patients in groups 1 and 2, respectively. In both groups, parietal lobe and cerebellum are the most and least common areas with hypoperfusion lesions, respectively. This study suggests that Tc-99m ECD brain SPECT may provide objective information for detection of hypoperfusion brain lesions in SLE patients.

摘要

利用锝-99m 半胱氨酸乙酯二聚体（Tc-99m ECD）脑单光子发射计算机断层扫描（SPECT）检测78例有神经精神症状的系统性红斑狼疮（SLE）患者的局部脑血流（rCBF）异常。这些患者被分为两个亚组：第1组包括48例有明确神经精神症状/体征的患者，第2组有30例无神经精神症状/体征的患者。Tc-99m ECD脑SPECT显示，第1组和第2组分别有90%和20%的患者存在脑灌注不足性病变。在两组中，顶叶和小脑分别是灌注不足性病变最常见和最不常见的区域。本研究提示，Tc-99m ECD脑SPECT可为检测SLE患者的脑灌注不足性病变提供客观信息。