Khorvash Fariborz, Shirani Elham, Askari Gholam Reza, Mousavi Seyed Ali, Sayedbonakdar Zahra, Fatemi Alimohammad
Isfahan Neurosciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
J Res Med Sci. 2013 Mar;18(Suppl 1):S47-50.
Neuropsychiatric abnormalities are among the most common manifestations of systemic lupus erythematosus (SLE). They have been proposed to be associated with impaired cerebral blood flow (CBF). Cerebral vasomotor reactivity (VMR) is a hemodynamic parameter effective in the autoregulation of CBF. The aim of the present study is to determine and compare the VMR of women with stable SLE and normal women.
According to the study criteria 60 women in each group entered the study. VMR was evaluated with Transcranial Doppler (TCD) at rest and after one minute of breath holding.
There was no significant difference in the mean of age between two groups (31.76 ± 7.50 years in the SLE group versus 32.43 ± 4.55 years in the control group, P value: 0.64). The mean duration of SLE in the case group was 5.40 ± 3.60 years. The means of the Breath-Holding Index (BHI) in the SLE and control groups were 0.842 ± 0.72% and 0.815 ± 0.26%, respectively, which was not significantly different (P value: 0.82).
This study indicates that the VMR of women with stable SLE is not significantly different from the age- and sex-matched normal population. However, further investigations on patients with longer SLE duration and more neuropsychological abnormality rates are suggested.
神经精神异常是系统性红斑狼疮(SLE)最常见的表现之一。有人提出它们与脑血流量(CBF)受损有关。脑血管运动反应性(VMR)是一种在CBF自动调节中有效的血流动力学参数。本研究的目的是确定并比较稳定期SLE女性和正常女性的VMR。
根据研究标准,每组60名女性进入研究。在静息状态和屏气1分钟后,用经颅多普勒(TCD)评估VMR。
两组之间的平均年龄无显著差异(SLE组为31.76±7.50岁,对照组为32.43±4.55岁,P值:0.64)。病例组SLE的平均病程为5.40±3.60年。SLE组和对照组的屏气指数(BHI)平均值分别为0.842±0.72%和0.815±0.26%,无显著差异(P值:0.82)。
本研究表明,稳定期SLE女性的VMR与年龄和性别匹配的正常人群无显著差异。然而,建议对病程更长、神经心理异常率更高的患者进行进一步研究。