Corberand J, Marty Y, Robert A, Regnier C
Arch Fr Pediatr. 1975 Oct;32(8):741-7.
A 7 week old infant was admitted for auto-immune hemolytic anemia, of progressive onset. Auto-antibodies were of IgG nature and of anti-e and anti-nl specificity. Treatment associated transfusions of leukocyte-free blood and corticosteroids reaching 4,5 mg/kg/day. Hemolysis stopped after 15 days and corticosteroid therapy was stopped without incident over 30 days. One month later, the clinical status was excellent, blood count was normal and immuno-hematological tests were negative. This case is a new one of the few auto-immune hemolytic anemias in children under 3 months of age. All showed an adequate immune development allowing the typical clinical and biological picture of an auto-immune disease, in spite of the classical idea of immunological immaturity, at this age.
一名7周大的婴儿因进行性起病的自身免疫性溶血性贫血入院。自身抗体为IgG性质，具有抗 - e和抗 - nl特异性。治疗方法包括输注去白细胞血液和使用皮质类固醇，剂量达4.5毫克/千克/天。15天后溶血停止，皮质类固醇治疗在30天内顺利停止。1个月后，临床状况良好，血细胞计数正常，免疫血液学检查呈阴性。该病例是3个月以下儿童中少数自身免疫性溶血性贫血的新病例之一。尽管按照传统观念，这个年龄段的儿童免疫不成熟，但所有病例都显示出足够的免疫发育，呈现出自身免疫性疾病典型的临床和生物学表现。
