Wilbur David C, Parker Elizabeth M, Foti Joseph A
Cytopathology Unit, ViaHealth, Rochester, NY, USA.
Am J Clin Pathol. 2002 Sep;118(3):399-407. doi: 10.1309/7LRF-DU8Q-8H1W-N7T4.
A 2-armed, masked study was performed on 1,275 AutoCyte PREP (TriPath, Burlington, NC) slides. Manual screening (current practice [CP]) was compared with automated screening with location-guided screening (LGS) using the AutoPap system with the SlideWizard 2 automated review microscopy station (TriPath). Cytologic adjudication determined "truth" for each slide. LGS identified more abnormal cases at all interpretive levels and classified abnormalities more specifically. For high-grade squamous intraepithelial lesions and above, the overall sensitivity of appropriate triage to pathologist review was 98.4% for LGS and 91.1% for CP. The appropriate triage for all abnormal cases was 92.1% for LGS and 87.9% for CP. The potential exists for more accurate and productive cytologic interpretation using this system, which requires no manual screening of a portion of slides and only limited review of another portion of "predotted" slides.
对1275张AutoCyte PREP（TriPath公司，北卡罗来纳州伯灵顿）玻片进行了一项双臂、盲法研究。将手工筛查（现行做法[CP]）与使用配备SlideWizard 2自动复查显微镜工作站（TriPath公司）的AutoPap系统进行的定位引导筛查（LGS）自动筛查进行比较。细胞学判定确定每张玻片的“真实情况”。LGS在所有解释水平上识别出更多异常病例，并且对异常的分类更具体。对于高级别鳞状上皮内病变及以上情况，LGS对病理学家复查的适当分流总体敏感性为98.4%，CP为91.1%。所有异常病例的适当分流率，LGS为92.1%，CP为87.9%。使用该系统存在进行更准确、高效的细胞学解释的潜力，该系统无需对部分玻片进行手工筛查，只需对另一部分“预标记”玻片进行有限复查。
