Harich N, Esteban E, López-Alomar A, Chafik A, Moral P
Départément de Biologie, Faculté des Sciences, Université Chouaïb Doukkali, El Jadida, Morocco, Spain.
Clin Genet. 2002 Sep;62(3):240-4. doi: 10.1034/j.1399-0004.2002.620310.x.
Apolipoprotein LPA, APOE, APOC1, and APOC2 genotype frequencies have been determined for the first time in a North African population. A sample of 140 Berber individuals from the Moroccan Moyen Atlas region has been analyzed. Allelic and haplotypic data have been used to compare our sample with other world populations and the results clearly differentiate Berbers from Europeans and Sub-Saharans, suggesting several distinctive features of Moroccan Berbers as the extreme high values of LPA PNR11 pentanucleotide allele (10.5%) and the relatively high and low values of APOEE4 (15.7%) and E2 (4.5%) in comparison to other Mediterraneans. Another remarkable result is the frequency distribution of the two APOC2 alleles (70% vs 30%) in comparison with the European pattern (50% of each allele). The high values of APOEE4 and LPA PNR*7 together with the intermediate linkage disequilibrium values between APOE and APOC1 alleles in comparison with Europeans and Africans suggest a certain degree of Sub-Saharan influence in the current Moroccan population.
首次在一个北非人群中确定了载脂蛋白LPA、APOE、APOC1和APOC2的基因型频率。对来自摩洛哥中阿特拉斯地区的140名柏柏尔人样本进行了分析。等位基因和单倍型数据已用于将我们的样本与其他世界人群进行比较，结果清楚地将柏柏尔人与欧洲人和撒哈拉以南非洲人区分开来，这表明摩洛哥柏柏尔人有几个独特特征，如LPA PNR11五核苷酸等位基因的极高值（10.5%）以及与其他地中海人群相比相对较高和较低的APOEE4（15.7%）和E2（4.5%）值。另一个显著结果是，与欧洲模式（每个等位基因占50%）相比，两个APOC2等位基因的频率分布（70%对30%）。与欧洲人和非洲人相比，APOEE4和LPA PNR*7的高值以及APOE和APOC1等位基因之间的中等连锁不平衡值表明当前摩洛哥人群受到了一定程度的撒哈拉以南非洲人的影响。
