Kontkanen Outi, Castrén Eero
Department of Neurobiology, A.I. Virtanen Institute and Department of Psychiatry, University of Kuopio, PO Box 1627, 70211 Kuopio, Finland.
Expert Opin Ther Targets. 2002 Jun;6(3):363-74. doi: 10.1517/14728222.6.3.363.
The rapidly accumulating amount of information concerning gene and protein expression patterns produced by functional genomics, proteomics and bioinformatics is presently providing new targets for drug development. Furthermore, the analysis of gene expression in cells and tissues affected by a disease may reveal the underlying metabolic pathways and cellular processes affected. Finally, changes in gene expression may be used in either diagnostics or the monitoring of drug responses. This review focuses on advances in the use of functional genomics in neurological and neuropsychiatric diseases and neuropsychopharmacology. Although the number of published studies in this field is still limited, it already appears that this strategy may become a fruitful means in the analysis of the aetiology of neuropsychiatric disorders and the search for novel neuropharmacological drugs.
功能基因组学、蛋白质组学和生物信息学所产生的关于基因和蛋白质表达模式的信息正在迅速积累，目前为药物开发提供了新的靶点。此外，对受疾病影响的细胞和组织中的基因表达进行分析，可能会揭示所影响的潜在代谢途径和细胞过程。最后，基因表达的变化可用于诊断或监测药物反应。本综述聚焦于功能基因组学在神经和神经精神疾病以及神经精神药理学中的应用进展。尽管该领域已发表的研究数量仍然有限，但似乎这一策略可能会成为分析神经精神疾病病因和寻找新型神经药理学药物的有效手段。
