Morales Bernardo, Choi Se-Young, Kirkwood Alfredo
Mind Brain Institute, Johns Hopkins University, Baltimore, Maryland 21218, USA.
J Neurosci. 2002 Sep 15;22(18):8084-90. doi: 10.1523/JNEUROSCI.22-18-08084.2002.
We studied the role of sensory experience in the maturation of GABAergic circuits in the rat visual cortex. Between the time at which the eyes first open and the end of the critical period for experience-dependent plasticity, the total GABAergic input converging into layer II/III pyramidal cells increases threefold. We propose that this increase reflects changes in the number of quanta released by presynaptic axons. Here, we show that the developmental increase in GABAergic input is prevented in animals deprived of light since birth but not in animals deprived of light after a period of normal experience. Thus, sensory experience appears to play a permissive role in the maturation of intracortical GABAergic circuits.
我们研究了感觉经验在大鼠视觉皮层GABA能神经回路成熟过程中的作用。从眼睛首次睁开到依赖经验的可塑性关键期结束这段时间内,汇聚到第II/III层锥体细胞的总GABA能输入增加了两倍。我们认为这种增加反映了突触前轴突释放的量子数量的变化。在此,我们表明,自出生起就被剥夺光照的动物中,GABA能输入的发育性增加受到了抑制,但在经过一段正常经验后被剥夺光照的动物中则没有。因此,感觉经验似乎在皮质内GABA能神经回路的成熟过程中起到了允许作用。