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成人过敏性紫癜伴肾小球肾炎和阵发性夜间血红蛋白尿:一种罕见的关联。

Adult Henoch-Schönlein purpura with glomerulonephritis and paroxysmal nocturnal haemoglobinuria: an uncommon association.

作者信息

Cozzi F, Botsios C, Ostuni P, Sfriso P, Piva E, Marson P, Punzi L, Todesco S

机构信息

University of Padua, Padua, Italy.

出版信息

Clin Rheumatol. 2002 Sep;21(5):408-10. doi: 10.1007/s100670200109.

DOI:10.1007/s100670200109
PMID:12223993
Abstract

Henoch-Schönlein purpura (HSP) is considered to be a small blood vessel systemic vasculitis. Numerous microorganisms have been implicated in triggering HSP. We describe an unusual case of HSP with glomerulonephritis and renal failure requiring haemodialysis in a young adult man who subsequently developed paroxysmal nocturnal haemoglobinuria (PNH) with several haemolytic episodes. Bacterial infections, especially those of the respiratory and urinary tract, might trigger both the diseases.

摘要

过敏性紫癜(HSP)被认为是一种小血管系统性血管炎。许多微生物被认为与HSP的触发有关。我们描述了一例不寻常的HSP病例,该患者为一名年轻成年男性,患有肾小球肾炎和肾衰竭,需要进行血液透析,随后又出现了阵发性夜间血红蛋白尿(PNH)并伴有多次溶血发作。细菌感染,尤其是呼吸道和泌尿道感染,可能会引发这两种疾病。

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引用本文的文献

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Complement Inhibition Therapy and Dialytic Strategies in Paroxysmal Nocturnal Hemoglobinuria: The Nephrologist's Opinion.阵发性睡眠性血红蛋白尿症的补体抑制疗法与透析策略:肾脏病学家的观点
J Clin Med. 2020 Apr 26;9(5):1261. doi: 10.3390/jcm9051261.
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Urological Manifestations of Henoch-Schonlein Purpura: A Review.过敏性紫癜的泌尿系统表现:综述
Curr Urol. 2015 Jul;8(2):66-73. doi: 10.1159/000365692. Epub 2015 Jul 10.
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The presence of CD55- and/or CD59-deficient erythrocytic populations in patients with rheumatic diseases reflects an immune-mediated bone-marrow derived phenomenon.
风湿性疾病患者中存在CD55和/或CD59缺陷的红细胞群体反映了一种免疫介导的骨髓源性现象。
Med Sci Monit. 2014 Jan 27;20:123-39. doi: 10.12659/MSM.889727.