Zhang Sujuan, Zhang Zhenxi, Jiang Dazong
Institute of Biomedical Engineering, Xi'an Jiaotong University, Xi'an 710049.
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2002 Jun;19(2):310-4.
As exogenous ALA (5-aminolevulinic acid) esters can induce the production and accumulation of endogenous photosensitizer PpIX (protoporphyrin IX) in tumor tissues more effectively, they have been the most active photosensitizer prodrug in PDT(photodynamic therapy) field. In this article, along with the procedure of ALA esters based PDT, some primary mechanism and experimental results were considered, which include: first, cellular uptake of ALA esters and its conversion into ALA; second, the production and accumulation of endogenous photosensitizer PpIX induced by eNdogenous ALA esters; last, the photosensitization of PpIX.
由于外源性5-氨基乙酰丙酸（ALA）酯能更有效地诱导肿瘤组织内源性光敏剂原卟啉IX（PpIX）的产生和积累，它们一直是光动力疗法（PDT）领域中最具活性的光敏剂前体药物。本文结合基于ALA酯的光动力治疗过程，探讨了一些主要机制和实验结果，包括：第一，ALA酯的细胞摄取及其向ALA的转化；第二，内源性ALA酯诱导内源性光敏剂PpIX的产生和积累；最后，PpIX的光致敏作用。
