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一种测定血清中茶碱的快速且精确的方法。

A rapid and precise method for determining theophylline in serum.

作者信息

Frings C S, Keefer R C, Saloom J M

出版信息

Clin Toxicol. 1975;8(5):553-61. doi: 10.3109/15563657508988100.

DOI:10.3109/15563657508988100
PMID:1222528
Abstract

We report a spectrophotometric method for determining theophylline that is useful as a routine method for monitoring serum theophylline concentrations. The recovery of theophylline from serum is essentially 100% whem compared with aqueous standards taken through the entire procedure. Barbiturates, which interfere with most ultraviolet spectrometric methods for theophylline, do not interfere with this method. The procedure requires less than 45 min for completion and is more sensitive than most spectrophotometric methods for determining theophylline.

摘要

我们报告了一种用于测定茶碱的分光光度法,该方法可作为监测血清茶碱浓度的常规方法。与整个过程中使用的水标准品相比,从血清中回收茶碱的回收率基本为100%。干扰大多数紫外光谱法测定茶碱的巴比妥类药物,并不干扰该方法。该方法完成测定所需时间不到45分钟,并且比大多数分光光度法测定茶碱更灵敏。

相似文献

1
A rapid and precise method for determining theophylline in serum.一种测定血清中茶碱的快速且精确的方法。
Clin Toxicol. 1975;8(5):553-61. doi: 10.3109/15563657508988100.
2
A modified ultraviolet spectrophotometric method for the determination of theophylline in serum in the presence of barbiturates.一种在存在巴比妥类药物的情况下测定血清中茶碱的改良紫外分光光度法。
Clin Chim Acta. 1976 Jun 15;69(3):491-5. doi: 10.1016/0009-8981(76)90123-6.
3
High-performance liquid chromatographic separation of caffeine, theophylline, theobromine and paraxanthine in rat brain and serum.大鼠脑和血清中咖啡因、茶碱、可可碱和副黄嘌呤的高效液相色谱分离
J Chromatogr. 1991 Sep 18;570(1):185-90. doi: 10.1016/0378-4347(91)80214-w.
4
Drug interference with the Schack and Waxler plasma theophylline assay.
Am J Hosp Pharm. 1977 May;34(5):496-9.
5
Isocratic liquid chromatographic determination of theophylline, acetaminophen, chloramphenicol, caffeine, anticonvulsants, and barbiturates in serum.
Ther Drug Monit. 1988;10(1):101-15.
6
Caffeine, theophylline and theobromine in pregnancy.孕期中的咖啡因、茶碱和可可碱。
Biol Res Pregnancy Perinatol. 1984;5(4):174-6.
7
[Detection of caffeine, theophylline and theobromine in the umbilical cord blood and breast milk].
Helv Paediatr Acta. 1985 Jul;40(2-3):163-7.
8
Ultraviolet spectrophotometric analysis of barbiturates: evaluation of potential interferences.巴比妥类药物的紫外分光光度分析:潜在干扰的评估
Am J Clin Pathol. 1973 Feb;59(2):167-73. doi: 10.1093/ajcp/59.2.167.
9
The simultaneous determination of theophylline, theobromine and caffeine in plasma by high performance liquid chromatography.高效液相色谱法同时测定血浆中的茶碱、可可碱和咖啡因。
Clin Biochem. 1980 Jun;13(3):132-4. doi: 10.1016/s0009-9120(80)90819-x.
10
A rapid and sensitive method for determination of theophylline in plasma and saliva by high pressure liquid chromatography.
Res Commun Chem Pathol Pharmacol. 1976 Oct;15(2):341-50.

引用本文的文献

1
Drug interferences with plasma assays in therapeutic drug monitoring.治疗药物监测中药物对血浆分析的干扰。
Clin Pharmacokinet. 1984 Jan-Feb;9(1):67-87. doi: 10.2165/00003088-198409010-00004.
2
Clinical pharmacokinetics of theophylline.茶碱的临床药代动力学
Clin Pharmacokinet. 1978 Jul-Aug;3(4):267-93. doi: 10.2165/00003088-197803040-00002.