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A clinical protocol for treatment of canine mammary tumors using encapsulated, cytochrome P450 synthesizing cells activating cyclophosphamide: a phase I/II study.

作者信息

Winiarczyk Stanislaw, Gradski Zbigniew, Kosztolich Barbara, Gabler Cornelia, König Gerhardt, Renner Matthias, Saller Robert M, Prosl Heinrich, Salmons Brian, Günzburg Walter H, Hain Johannes

机构信息

Department of Epizootiology and Clinic of Infectious Diseases, Faculty of Veterinary Medicine, Agriculture University, Gleboka Street 30, 20612 Lublin, Poland.

出版信息

J Mol Med (Berl). 2002 Sep;80(9):610-4. doi: 10.1007/s00109-002-0356-0. Epub 2002 Jun 28.

DOI:10.1007/s00109-002-0356-0
PMID:12226743
Abstract
摘要

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A clinical protocol for treatment of canine mammary tumors using encapsulated, cytochrome P450 synthesizing cells activating cyclophosphamide: a phase I/II study.一项使用包封的、合成细胞色素P450激活环磷酰胺治疗犬乳腺肿瘤的临床方案：一项I/II期研究。
J Mol Med (Berl). 2002 Sep;80(9):610-4. doi: 10.1007/s00109-002-0356-0. Epub 2002 Jun 28.
2
Phase I/II clinical trial of encapsulated, cytochrome P450 expressing cells as local activators of cyclophosphamide to treat spontaneous canine tumours.作为环磷酰胺局部激活剂治疗自发性犬类肿瘤的细胞色素P450表达封装细胞的I/II期临床试验。
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3
Injection of encapsulated cells producing an ifosfamide-activating cytochrome P450 for targeted chemotherapy to pancreatic tumors.注射包封细胞以产生异环磷酰胺激活细胞色素P450用于胰腺肿瘤的靶向化疗。
Ann N Y Acad Sci. 1999 Jun 30;880:337-51. doi: 10.1111/j.1749-6632.1999.tb09537.x.
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Intratumoral injection of encapsulated cells producing an oxazaphosphorine activating cytochrome P450 for targeted chemotherapy.瘤内注射包囊细胞，这些细胞可产生一种激活细胞色素P450的恶唑磷用于靶向化疗。
Adv Exp Med Biol. 1998;451:97-106. doi: 10.1007/978-1-4615-5357-1_16.
5
Enhanced antitumor activity of P450 prodrug-based gene therapy using the low Km cyclophosphamide 4-hydroxylase P450 2B11.使用低Km环磷酰胺4-羟化酶P450 2B11的基于P450前药的基因疗法增强抗肿瘤活性。
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Targeted chemotherapy by intratumour injection of encapsulated cells engineered to produce CYP2B1, an ifosfamide activating cytochrome P450.通过瘤内注射经基因工程改造以产生CYP2B1（一种异环磷酰胺激活细胞色素P450）的封装细胞进行靶向化疗。
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Diffusible cytotoxic metabolites contribute to the in vitro bystander effect associated with the cyclophosphamide/cytochrome P450 2B1 cancer gene therapy paradigm.可扩散的细胞毒性代谢产物促成了与环磷酰胺/细胞色素P450 2B1癌症基因治疗模式相关的体外旁观者效应。
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Necrotic, rather than apoptotic, cell death caused by cytochrome P450-activated ifosfamide.细胞色素P450激活异环磷酰胺引起的是坏死性细胞死亡，而非凋亡性细胞死亡。
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本文引用的文献

1
Microencapsulated cell-mediated treatment of inoperable pancreatic carcinoma.
Lancet. 2001 May 19;357(9268):1591-2. doi: 10.1016/s0140-6736(00)04749-8.
2
Adjuvant post-operative chemotherapy in bitches with mammary cancer.患有乳腺癌的母犬术后辅助化疗。
J Vet Med A Physiol Pathol Clin Med. 2001 Mar;48(2):85-96. doi: 10.1046/j.1439-0442.2001.00336.x.
3
Factors influencing the incidence and prognosis of canine mammary tumours.影响犬乳腺肿瘤发病率和预后的因素。
J Small Anim Pract. 2000 Jul;41(7):287-91. doi: 10.1111/j.1748-5827.2000.tb03203.x.
作为环磷酰胺局部激活剂治疗自发性犬类肿瘤的细胞色素P450表达封装细胞的I/II期临床试验。
PLoS One. 2014 Jul 16;9(7):e102061. doi: 10.1371/journal.pone.0102061. eCollection 2014.
4
Combined chemotherapy of murine mammary tumors by local activation of the prodrugs ifosfamide and 5-fluorocytosine.通过前体药物异环磷酰胺和5-氟胞嘧啶的局部激活对小鼠乳腺肿瘤进行联合化疗。
Cancer Gene Ther. 2000 Apr;7(4):629-36. doi: 10.1038/sj.cgt.7700139.
5
Characterization of a human cell clone expressing cytochrome P450 for safe use in human somatic cell therapy.
Ann N Y Acad Sci. 1999 Jun 30;880:326-36. doi: 10.1111/j.1749-6632.1999.tb09536.x.
6
Development of cellulose sulfate-based polyelectrolyte complex microcapsules for medical applications.
Ann N Y Acad Sci. 1999 Jun 18;875:46-63. doi: 10.1111/j.1749-6632.1999.tb08493.x.
7
Cell therapy using microencapsulated 293 cells transfected with a gene construct expressing CYP2B1, an ifosfamide converting enzyme, instilled intra-arterially in patients with advanced-stage pancreatic carcinoma: a phase I/II study.
J Mol Med (Berl). 1999 Apr;77(4):393-8. doi: 10.1007/s001090050366.
8
Targeted chemotherapy by intratumour injection of encapsulated cells engineered to produce CYP2B1, an ifosfamide activating cytochrome P450.通过瘤内注射经基因工程改造以产生CYP2B1（一种异环磷酰胺激活细胞色素P450）的封装细胞进行靶向化疗。
Gene Ther. 1998 Aug;5(8):1070-8. doi: 10.1038/sj.gt.3300671.
9
The increasing efficacy of breast cancer treatment.乳腺癌治疗效果的不断提高。
Clin Oncol (R Coll Radiol). 1997;9(5):338-42. doi: 10.1016/s0936-6555(05)80069-x.
10
Brain and plasma pharmacokinetics and anticancer activities of cyclophosphamide and phosphoramide mustard in the rat.环磷酰胺和磷酰胺芥在大鼠体内的脑和血浆药代动力学及抗癌活性
Cancer Chemother Pharmacol. 1990;27(1):1-7. doi: 10.1007/BF00689268.